Evaluation of vasovagal reaction during autologous blood donation

• Project/Area Number: 26861895
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical nursing
• Research Institution: Miyagi University
• Principal Investigator: KAMAKURA Miho 宮城大学, 看護学群(部), 助教 (80700020)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: Autonomic nervous system / Heart rate variability / Vaso-vagal reaction / Glycated hemoglobin

Outline of Final Research Achievements

We aimed to evaluate changes in cardiac autonomic nervous activity during autologous blood donation for decreasing the risk of vasovagal reaction.
Preoperative patients who were scheduled for autologous blood donation for intraoperative or postoperative use were enrolled. We recorded electrocardiographic data throughout autologous blood donation to evaluate autonomic nervous activity by using spectral analysis of heart rate variability. First-time blood donors have a significantly higher incidence of vasovagal reaction (VVR). In the patient with VVR and first-time blood donors, autonomic nervous activity showed specific responses during autologous blood donation.

Research Products

• [Journal Article] Elevated HbA1c Levels Are Associated with the Blunted Autonomic Response Assessed by Heart Rate Variability during Blood Volume Reduction (2016)
  • Author(s): Miho Kamakura, Ryoko Maruyama
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 240 Issue: 2 Pages: 91-100
  • DOI: 10.1620/tjem.240.91
  • NAID: 130006776934
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Decreased age-related autonomic function poses a risk for unstable cardiovascular dynamics: monitoring changes in circulating blood volume (2017)
  • Author(s): Miho Kamakura, Emi Kanno, HiromasaTanno, Ryoko Maruyama.
  • Organizer: American Physiological Society
  • Int'l Joint Research
• [Presentation] Comparison of the effects of a difference in blood donation experience on the autonomic response and cardiovascular dynamics during mild blood loss (2016)
  • Author(s): Miho Kamakura, Minami Yamada-Fujiwara, Emi Kanno, Ryoko Maruyama.
  • Organizer: American Thoracic Society 2016 International Conference
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] A case of vasovagal reaction evaluated by heart rate variability analysis during autologous blood donation (2015)
  • Author(s): Kamakura, M. Kanno, E. Maruyama, R.
  • Organizer: American Thoracic Society: ATS Conference 2015
  • Place of Presentation: Denver, USA
  • Year and Date: 2015-05-18
  • Int'l Joint Research