| Project/Area Number |
26870016
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
Periodontology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KATO Akihito 北海道大学, 歯学研究科, 助教 (40507571)
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| Research Collaborator |
NISHIDA Erika
TATEYAMA Akito
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 歯周組織再生 / エマルション / 骨ペースト / 多孔質体 / 骨増生効果 / 生体親和性 / イングロース / スキャフォールド / 再生医学 / 動物実験 / PLGA |
|---|
| Outline of Final Research Achievements |
We developed bone paste using particle emulsion of α-Tricalcium phosphate (α-TCP) and Poly(lactic-co-glycolic) acid (PLGA), and evaluated the ability as bone regeneration material in vivo and in vitro. As a result, emulsion bone paste showed good biocompatibility in vivo, and more cell invasion into the material was observed by PLGA addition. If this new bone paste can be applied to periodontal disease, it is expected that a large amount of cells in the surrounding will invade the material, and it will be possible to obtain the effect of regeneration over conventional bone graft material.
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