| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The low-birth-weight (LBW) baby have increases due to the in appropriate nourishment, lack of exercise and mental distress in pregnant women. It is thought that LBW baby has been developed to the adult disease; life-style disease, several cancers and mental depression. This finding could be an explanation of the epigenetic effect of the placenta. Firstly, we examined to what factors is associated with the LBW babies. Secondly, we performed genome-wide allelic DNA methylation analyses of purified trophoblast cells from human placentas. RNA sequencing-based allelic expression analyses revealed whether imprinted gene expression is correct or not. We found the LBW risk was associated with smoking and loss of imprinting in their placenta cells (80%).
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