Analysis of the role of BACH2 alterations in B-cell lymphoma
| Project/Area Number |
26870038
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
Laboratory medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 悪性リンパ腫 / BACH2 |
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| Outline of Final Research Achievements |
The clinicopathological analysis in diffuse large B-cell lymphoma (DLBCL) resulted that BACH2, a B cell-specific transcriptional repressor, may be a prognostic marker in the DLBCL with MYC translocation. Among the biological parameters of B-cell lymphoma, BACH2 is independent of other factors, including BCL2 and BCL6, in DLBCL with MYC translocation.
Double hit lymphoma, which is DLBCL with both MYC and BCL2 translocation, is rare subtype associated with an extremely poor prognosis. Transformed follicular lymphoma (FL) occurred as a part of double hit lymphoma, we analyzed BACH2, MYC and BCL2 genomic alteration and expression in FL. A half of MYC genomic alterations occurred in grade 1-2 FL. BACH2 expression is associated with histological grade and BCL2 translocation in FL.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Monitoring of minimal residual disease in early T-cell precursor acute lymphoblastic leukaemia by next-generation sequencing2016
Author(s)
Pan X, Nariai N, Fukuhara N, Saito S, Sato Y, Katsuoka F, Kojima K, Kuroki Y, Danjoh I, Saito R, Hasegawa S, Okitsu Y, Kondo A, Onishi Y, Nagami F, Kiyomoto H, Hozawa A, Fuse N, Nagasaki M, Shimizu R, Yasuda J, Harigae H, Yamamoto M
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Journal Title
Br J Haematol
Volume: in press
Issue: 2
Pages: 318-321
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma.2014
Author(s)
Ichikawa, S., Fukuhara, N., Katsushima, H., Takahashi, T., Yamamoto, J., Yokoyama, H., Sasaki, O., Fukuhara, O., Nomura, J., Ishizawa, K., Ichinohasama, R., Muto, A., Igarashi, K., and Harigae, H.
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Journal Title
Cancer Science
Volume: in press
Issue: 4
Pages: 437-444
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis.2014
Author(s)
Suguro M, Yoshida N, Umino A, Kato H, Tagawa H, Nakagawa M, Fukuhara N, Karnan S, Takeuchi I, Hocking TD, Arita K, Karube K, Tsuzuki S, Nakamura S, Kinoshita T, Seto M.
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Journal Title
Cancer Sci.
Volume: 105
Issue: 7
Pages: 897-904
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prognostic significance of pleural or pericardial effusion and the implication of optimal treatment in primary mediastinal large B-cell lymphoma: a multicenter retrospective study in Japan.2014
Author(s)
Aoki T, Izutsu K, Suzuki R, Nakaseko C, Arima H, Shimada K, Tomita A, Sasaki M, Takizawa J, Mitani K, Igarashi T, Maeda Y, Fukuhara N, Ishida F, Niitsu N, Ohmachi K, Takasaki H, Nakamura N, Kinoshita T, Nakamura S, Ogura M.
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Journal Title
Haematologica
Volume: 99(12)
Issue: 12
Pages: 1817-25
DOI
Related Report
Peer Reviewed / Open Access
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