Analysis of the role of BACH2 alterations in B-cell lymphoma

• Project/Area Number: 26870038
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology; Laboratory medicine
• Research Institution: Tohoku University
• Principal Investigator: FUKUHARA NORIKO 東北大学, 大学病院, 講師 (10534167)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 悪性リンパ腫 / BACH2

Outline of Final Research Achievements

The clinicopathological analysis in diffuse large B-cell lymphoma (DLBCL) resulted that BACH2, a B cell-specific transcriptional repressor, may be a prognostic marker in the DLBCL with MYC translocation. Among the biological parameters of B-cell lymphoma, BACH2 is independent of other factors, including BCL2 and BCL6, in DLBCL with MYC translocation.
Double hit lymphoma, which is DLBCL with both MYC and BCL2 translocation, is rare subtype associated with an extremely poor prognosis. Transformed follicular lymphoma (FL) occurred as a part of double hit lymphoma, we analyzed BACH2, MYC and BCL2 genomic alteration and expression in FL. A half of MYC genomic alterations occurred in grade 1-2 FL. BACH2 expression is associated with histological grade and BCL2 translocation in FL.

Research Products

• [Journal Article] Advanced Lymphocyte-rich Classical Hodgkin Lymphoma Complicated with Fatal Hemophagocytic Syndrome (2016)
  • Author(s): Ichikawa S, Takahashi T, Katsushima H, Fukuhara N, Ichinohasama R, Harigae H.
  • Journal Title: Internal Medicine Volume: 55 Issue: 2 Pages: 191-196
  • DOI: 10.2169/internalmedicine.55.5942
  • NAID: 130005119764
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Monitoring of minimal residual disease in early T-cell precursor acute lymphoblastic leukaemia by next-generation sequencing (2016)
  • Author(s): Pan X, Nariai N, Fukuhara N, Saito S, Sato Y, Katsuoka F, Kojima K, Kuroki Y, Danjoh I, Saito R, Hasegawa S, Okitsu Y, Kondo A, Onishi Y, Nagami F, Kiyomoto H, Hozawa A, Fuse N, Nagasaki M, Shimizu R, Yasuda J, Harigae H, Yamamoto M
  • Journal Title: Br J Haematol Volume: in press Issue: 2 Pages: 318-321
  • DOI: 10.1111/bjh.13948
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of a novel putative mitochondrial protein FAM210B associated with erythroid differentiation. (2016)
  • Author(s): Kondo A, Fujiwara T, Okitsu Y, Fukuhara N, Onishi Y, Nakamura Y, Sawada K, Harigae H.
  • Journal Title: International Journal of Hematology Volume: Mar 11
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 濾胞性リンパ腫 (2016)
  • Author(s): 福原規子
  • Journal Title: medicina Volume: 52 Pages: 2095-2100
  • NAID: 130007642895
• [Journal Article] 濾胞性リンパ腫に対する合理的な治療戦略 (2016)
  • Author(s): 福原規子
  • Journal Title: 血液内科 Volume: 72 Pages: 51-55
• [Journal Article] High-Throughput siRNA Screening to Reveal GATA-2 Upstream Transcriptional Mechanisms in Hematopoietic Cells. (2015)
  • Author(s): Saito Y, Fujiwara T, Ohashi K, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Harigae H.
  • Journal Title: PLoS One Volume: 10 Issue: 9 Pages: e0137079-e0137079
  • DOI: 10.1371/journal.pone.0137079
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heparin-responsive angiopathy in the central nervous system caused by intravasular large B-cell lymphoma. (2015)
  • Author(s): Yoshida S, Fukuhara N, Aoki M.
  • Journal Title: J Neurol Sci. Volume: 352 Issue: 1-2 Pages: 117-119
  • DOI: 10.1016/j.jns.2015.03.026
  • Peer Reviewed
• [Journal Article] びまん性大細胞型B細胞リンパ腫におけるBACH2発現の臨床病理学的意義 (2015)
  • Author(s): 市川聡、福原規子
  • Journal Title: 血液内科 科学評論社 Volume: 1 Pages: 82-86
  • NAID: 40020341682
  • Peer Reviewed / Open Access
• [Journal Article] Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma. (2014)
  • Author(s): Ichikawa, S., Fukuhara, N., Katsushima, H., Takahashi, T., Yamamoto, J., Yokoyama, H., Sasaki, O., Fukuhara, O., Nomura, J., Ishizawa, K., Ichinohasama, R., Muto, A., Igarashi, K., and Harigae, H.
  • Journal Title: Cancer Science Volume: in press Issue: 4 Pages: 437-444
  • DOI: 10.1111/cas.12361
  • Peer Reviewed / Open Access
• [Journal Article] Fatal visceral varicella-zoster developing early after autologous hematopoietic stem cell transplantation for refractory diffuse large B-cell lymphoma. (2014)
  • Author(s): Ichikawa S, Fukuhara N
  • Journal Title: J Clin Exp Hematop. Volume: 54 Pages: 237-241
  • NAID: 130004705271
  • Peer Reviewed / Open Access
• [Journal Article] Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis. (2014)
  • Author(s): Suguro M, Yoshida N, Umino A, Kato H, Tagawa H, Nakagawa M, Fukuhara N, Karnan S, Takeuchi I, Hocking TD, Arita K, Karube K, Tsuzuki S, Nakamura S, Kinoshita T, Seto M.
  • Journal Title: Cancer Sci. Volume: 105 Issue: 7 Pages: 897-904
  • DOI: 10.1111/cas.12442
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of acquired mutations by whole-genome sequencing in GATA-2 deficiency evolving into myelodysplasia and acute leukemia. (2014)
  • Author(s): Fujiwara T, Fukuhara N
  • Journal Title: Ann Hematol Volume: 93 Pages: 1515-1522
  • Peer Reviewed
• [Journal Article] Prognostic significance of pleural or pericardial effusion and the implication of optimal treatment in primary mediastinal large B-cell lymphoma: a multicenter retrospective study in Japan. (2014)
  • Author(s): Aoki T, Izutsu K, Suzuki R, Nakaseko C, Arima H, Shimada K, Tomita A, Sasaki M, Takizawa J, Mitani K, Igarashi T, Maeda Y, Fukuhara N, Ishida F, Niitsu N, Ohmachi K, Takasaki H, Nakamura N, Kinoshita T, Nakamura S, Ogura M.
  • Journal Title: Haematologica Volume: 99(12) Issue: 12 Pages: 1817-25
  • DOI: 10.3324/haematol.2014.111203
  • Peer Reviewed / Open Access
• [Presentation] Minimal residual disease monitoring by next-generation sequencing in ETP-ALL (2015)
  • Author(s): Noriko Fukuhara, Jun Yasuda，Hideo Harigae
  • Organizer: 日本血液学会
  • Place of Presentation: 石川県立音楽堂 他、金沢市
  • Year and Date: 2015-10-18
• [Presentation] Phase II study of R-High-CHOP/CHASER followed by LEED therapy with ASCT in untreated MCL (JCOG0406) (2015)
  • Author(s): Dai Maruyama，Noriko Fukuhara，Michinori Ogura
  • Organizer: 日本血液学会
  • Place of Presentation: 石川県立音楽堂 他、金沢市
  • Year and Date: 2015-10-16
• [Presentation] R-MVP therapy with whole-brain radiotherapy for primary intraocular lymphoma (2015)
  • Author(s): Kei Saito, Noriko Fukuhara, Ryo Ichinohasama, Hideo Harigae
  • Organizer: 日本血液学会
  • Place of Presentation: 石川県立音楽堂 他、金沢市
  • Year and Date: 2015-10-16
• [Presentation] The clinical significance of BACH2 expression in diffuse large B-cell lymphoma (2014)
  • Author(s): Ichikawa Satoshi, Fukuhara Noriko
  • Organizer: 日本血液学会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Prognostic significance of pleural/pericardial effusion, and the optimal treatment in PMBL (2014)
  • Author(s): Aoki Tomohiro, Fukuhara Noriko, Ogura Michinori
  • Organizer: 日本血液学会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Whole genome sequencing to identify acquired mutations in MonoMAC syndrome evolving into MDS/AML (2014)
  • Author(s): Fujiwara Tohru, Fukuhara Noriko
  • Organizer: 日本血液学会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Adult MDS cases diagnosed as MonoMAC syndrome (2014)
  • Author(s): Nakagawa Ryo, Fukuhara Noriko
  • Organizer: 日本血液学会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] FR therapy followed by 90Y-ibritumomab tiuxetan for relapsed indolent B cell lymphoma, phase I study (2014)
  • Author(s): Himuro Masahito, Noriko Fukuhara
  • Organizer: 日本血液学会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] 多発脳神経障害で発症し進行性の馬尾病変をきたした原発性神経リンパ腫症の一例 (2014)
  • Author(s): 加藤浩貴、福原規子
  • Organizer: 日本リンパ網内系学会
  • Place of Presentation: 山形市
  • Year and Date: 2014-06-19 – 2014-06-21
• [Presentation] 骨髄生検でB-リンパ芽球性白血病/リンパ腫と濾胞性リンパ腫が同時に認められた一 (2014)
  • Author(s): 勝嶌 浩紀、福原規子、一迫玲
  • Organizer: 日本病理学会
  • Place of Presentation: 広島市
  • Year and Date: 2014-04-24 – 2014-04-26
• [Book] 悪性リンパ腫治療マニュアル 改訂第4版 (2015)
  • Author(s): 飛内賢正、木下朝博、塚崎邦弘 福原規子、ほか
  • Total Pages: 336
  • Publisher: 南江堂
• [Book] 血液領域の分子標的治療薬 (2015)
  • Author(s): 福原規子
  • Total Pages: 198
  • Publisher: 最新医学社
• [Book] 抗がん剤の副作用と支持療法 (2015)
  • Author(s): 福原規子
  • Total Pages: 731
  • Publisher: 日本臨牀
• [Book] リンパ腫アトラス第４版 (2014)
  • Author(s): 福原規子、一迫玲
  • Total Pages: 407
  • Publisher: 文光堂
• [Book] がんの薬物療法マニュアル (2014)
  • Author(s): 福原規子
  • Total Pages: 540
  • Publisher: 中外医学社