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Iron metabolism and mitochondria-related disease

Research Project

Project/Area Number 26870067
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Cell biology
Research InstitutionYamagata University

Principal Investigator

TANAKA ATSUSHI  山形大学, 医学部, 准教授 (60404000)

Research Collaborator OTSUKA Rina  
INOUE Hiroaki  
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsミトコンドリア / 鉄代謝 / 小胞 / 神経変性疾患 / オートファジー / 品質管理 / 鉄動態 / 膜ダイナミクス
Outline of Final Research Achievements

Mitochondria produce cellular energy in response to cellular demands. Accumulation of dysfunctional mitochondria due to impaired quality control system, links to multiple human disorders. Recent studies revealed that elimination of damaged mitochondria through the autophagy is important for the quality and quantity control of them.
We have revealed that autophagy-deficient mice develop multiple liver tumors with accumulation of cellular stress and damaged mitochondria. During mitochondrial collapse in autophagy deficit tissues, we observed that liver mitochondria in autophagy-deficient mice show decreased iron content, however total iron contents in a cell is normal. These results suggested that insufficiently amounts of iron cause deformation of oxidative phosphorylation complex in a mitochondrion, then mitochondrion turn to be inactive. Alos abnormal iron distribution in a cell might cause an aggravating factor for the cellular environment, such as a trigger for fenton reaction.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (9 results) (of which Invited: 2 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] McGill University(カナダ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Freiburg University(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis2015

    • Author(s)
      Narumi T, Shishido T, Otaki Y, Kadowaki S, Honda Y, Funayama A, Honda S, Hasegawa H, Kinoshita D, Yokoyama M, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Tanaka A, Woo C, Abe J, Takeishi Y, Kubota I
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 82 Pages: 1-12

    • DOI

      10.1016/j.yjmcc.2015.02.018

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.2014

    • Author(s)
      Tamiya G, Makino S, Hayashi M, Abe A, Numakura C, Ueki M, Tanaka A, Ito C, Toshimori K, Ogawa N, Terashima T, Maegawa H, Yanagisawa D, Tooyama I, Tada M, Onodera O, Hayasaka K.
    • Journal Title

      Am J Hum Genet.

      Volume: 95 Issue: 3 Pages: 294-300

    • DOI

      10.1016/j.ajhg.2014.07.013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 鉄代謝阻害に応答するミトコンドリア由来小胞の形成とその詳細2015

    • Author(s)
      田中 敦、井上 弘章、大塚 理奈、Heidi McBride
    • Organizer
      第88回日本生化学会・第38回分子生物学会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞内ストレスに応答するミトコンドリア由来小胞の形成メカニズム2015

    • Author(s)
      井上 弘章、大塚 理奈、田中 敦
    • Organizer
      第88回日本生化学会・第38回分子生物学会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] ストレス応答性ミトコンドリア由来小胞の形成とリソソームとの関係2015

    • Author(s)
      田中 敦
    • Organizer
      第9回オートファジー研究会・第3回「オートファジー」班会議
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県淡路市)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞内鉄異常とミトコンドリアストレス応答のメカニズム2015

    • Author(s)
      田中 敦、井上 弘章、大塚 理奈、水島 昇
    • Organizer
      第39回日本鉄バイオサイエンス学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ストレス応答性ミトコンドリア由来小胞の形成と鉄代謝の関係性2014

    • Author(s)
      田中敦
    • Organizer
      第14回日本ミトコンドリア学会年会
    • Place of Presentation
      九州大学医学部百年講堂(福岡)
    • Year and Date
      2014-12-03 – 2014-12-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Analysis of mitochondria-derived vesicle formation in response to cellular stress2014

    • Author(s)
      Tanaka A
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 細胞内に取り込まれた鉄の動態とミトコンドリア機能維持の関係性2014

    • Author(s)
      田中敦
    • Organizer
      第87回日本生化学会年会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Analysis of mitochondria-derived vesicle formation in response to cellular stress2014

    • Author(s)
      Oshikiri Y, Tanaka A
    • Organizer
      第87回日本生化学会年会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 細胞内鉄の動態とミトコンドリア機能維持メカニズムの関係2014

    • Author(s)
      田中敦
    • Organizer
      第38回日本鉄バイオサイエンス学会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2014-09-06 – 2014-09-07
    • Related Report
      2014 Research-status Report
  • [Book] 実験医学 2014年9月号 クローズアップ実験法「さまざまなモデル生物からミトコンドリア画分を分離する簡便な方法」2014

    • Author(s)
      田中敦(責任監修), 岡本徳子, 風間智彦
    • Publisher
      羊土社
    • Related Report
      2014 Research-status Report
  • [Remarks] 研究室HP

    • URL

      http://tanaka.yu-med-tenure.com

    • Related Report
      2015 Annual Research Report
  • [Remarks] 田中敦研究室ホームページ

    • URL

      http://tanaka.yu-med-tenure.com

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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