Regulation of the differentiation of pathogenic T cells in autoimmune arthritis
Project/Area Number |
26870081
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
Collagenous pathology/Allergology
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Research Institution | University of Tsukuba |
Principal Investigator |
Kondo Yuya 筑波大学, 医学医療系, 講師 (40612487)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 自己免疫性関節炎 / T細胞 / 分化 / 転写因子 / サイトカイン / 関節リウマチ / 細胞内シグナル |
Outline of Final Research Achievements |
We have examined the role of transcription factors regulating the differentiation of CD4+ T cells in the development of autoimmune arthritis.In the analyses of animal model of autoimmune arthritis, we showed the possibility that Th-17 specific master transcription factor RORgt-expressing Foxp3+ regulatory T cells might regulate the development of autoimmune arthritis via the suppression of arthritogenic Th-17 cells in RORgt trangenic mice (Kondo Y et al. Arthritis Res Ther 2015). Our results suggested possibility that control of the differentiation of CD4+ T cells might be a novel therapeutic strategy in autoimmune arthritis.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Involvement of RORγt-overexpressing T cells in the development of autoimmune arthritis in mice2015
Author(s)
Yuya Kondo, Zhaojin Yao, Masahiro Tahara, Mana Iizuka, Masahiro Yokosawa, Shunta Kaneko, Seiji Segawa, Hiroto Tsuboi, Keigyou Yoh, Satoru Takahashi, Isao Matsumoto and Takayuki Sumida
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Journal Title
Arthritis Research & Therapy
Volume: 17
Issue: 1
Pages: 105-105
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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