Development of early diagnostic method of prion diseases by a fluorescence correlation spectroscopic device with optical nano antenna structures
| Project/Area Number |
26870089
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
Analytical chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 表面プラズモン / 蛍光相関分光法 / バイオセンサー / ナノフォトニクス / プラズモン / ナノ粒子 |
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| Outline of Final Research Achievements |
In order to analyze abnormal-type prion proteins as an index of prion disease with high accuracy, rapid and throughput, we have developed a system of highly sensitive fluorescence correlation spectroscopy using enhancement of electric field in the gap region between metal nano structures. First, we developed the method to efficiently build optical nano antenna structures by connecting gold nano rods synthesized by the seed method via organic linker molecules. We also got preliminary results of FCS based on our integrated system although fine optimization of excitation light source and surface modification of the metal nano structures are required.
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Report
(3 results)
Research Products
(6 results)
