| Project/Area Number |
26870099
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
Medical genome science
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| Research Institution | Chiba University |
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Principal Investigator |
SATO YASUNORI 千葉大学, 大学院医学研究院, 准教授 (90536723)
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| Research Collaborator |
YOSHIDA TERUHIKO
OKUSAKA TAKUSHI
UENO HIDEKI
Laird Nan
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵癌 / ゲノム網羅的解析 / ファーマコゲノミクス / バイオマーカー / 薬剤反応性遺伝子 / 生物統計手法 / 切除不能進行膵癌 / 有害事象 / imputation / 生存時間解析 / ゲノム網羅的関連解析 |
|---|
| Outline of Final Research Achievements |
We employed genome-wide pharmacogenomics studies to identify candidate polymorphisms that could influence overall survival (OS) or adverse effects (AEs) in advanced pancreatic cancer (PC) patients. As a result, advanced PC patients with the rs4149086 AG or GG genotype may obtain good clinical results when treated with S-1 containing regimens. Additionally, we detected the candidate SNPs which could influence OS or AEs in genome-wide association study (GWAS). And also, we developed a new statistical method for detecting candidate SNPs in a GWAS.
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