Pharmacogenomics study for prediction of treatment effects and side effects in pancreatic cancer

• Project/Area Number: 26870099
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology; Medical genome science
• Research Institution: Chiba University
• Principal Investigator: SATO YASUNORI 千葉大学, 大学院医学研究院, 准教授 (90536723)
• Research Collaborator: YOSHIDA TERUHIKO ; OKUSAKA TAKUSHI ; UENO HIDEKI ; Laird Nan
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 膵癌 / ゲノム網羅的解析 / ファーマコゲノミクス / バイオマーカー / 薬剤反応性遺伝子 / 生物統計手法 / 切除不能進行膵癌 / 有害事象 / imputation / 生存時間解析 / ゲノム網羅的関連解析

Outline of Final Research Achievements

We employed genome-wide pharmacogenomics studies to identify candidate polymorphisms that could influence overall survival (OS) or adverse effects (AEs) in advanced pancreatic cancer (PC) patients. As a result, advanced PC patients with the rs4149086 AG or GG genotype may obtain good clinical results when treated with S-1 containing regimens. Additionally, we detected the candidate SNPs which could influence OS or AEs in genome-wide association study (GWAS). And also, we developed a new statistical method for detecting candidate SNPs in a GWAS.

Research Products

• [Int'l Joint Research] Department of Biostatistics/Harvard School of Public Health(米国)
• [Int'l Joint Research] Department of Biostatistics/Harvard School of Public Health(米国)
• [Journal Article] Statistical Methods in the Journal - An Update. (2017)
  • Author(s): Sato Y, Gosho M, Nagashima K, Takahashi S, Ware JH, Laird NM.
  • Journal Title: New England Journal of Medicine Volume: 376 Issue: 11 Pages: 1086-1087
  • DOI: 10.1056/nejmc1616211
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 医学・薬学研究における統計モデル解析 (2016)
  • Author(s): 佐藤泰憲, 長島健悟, 高橋翔
  • Journal Title: Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology Volume: 30 Issue: 4 Pages: 580-586
  • DOI: 10.3388/jspaci.30.580
  • NAID: 130005268362
  • ISSN: 0914-2649, 1882-2738
  • Peer Reviewed
• [Journal Article] 医学・薬学研究における症例数設計 (2016)
  • Author(s): 佐藤泰憲, 長島健悟, 高橋翔
  • Journal Title: Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology Volume: 30 Issue: 2 Pages: 190-197
  • DOI: 10.3388/jspaci.30.190
  • NAID: 130005160479
  • ISSN: 0914-2649, 1882-2738
  • Peer Reviewed
• [Journal Article] 医学・薬学研究における生存時間データの統計解析 (2016)
  • Author(s): 佐藤泰憲, 長島健悟, 高橋翔
  • Journal Title: Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology Volume: 30 Issue: 5 Pages: 659-665
  • DOI: 10.3388/jspaci.30.659
  • NAID: 130005297308
  • ISSN: 0914-2649, 1882-2738
  • Peer Reviewed
• [Journal Article] 臨床研究における生物統計学の基礎. 日本小児アレルギー学会誌 (2015)
  • Author(s): 佐藤泰憲, 五所正彦
  • Journal Title: 日本小児アレルギー学会誌 Volume: ２９（１） Pages: 79-85
  • Peer Reviewed
• [Journal Article] 臨床試験の計画：試験デザインとデータ解析 (2015)
  • Author(s): 佐藤泰憲、高橋翔、長島健悟.
  • Journal Title: 日本小児アレルギー学会誌 Volume: ２９（２） Pages: 214-221
  • NAID: 130005099400
  • Peer Reviewed
• [Journal Article] 疫学研究の計画：研究デザインとデータ解析 (2015)
  • Author(s): 佐藤泰憲、長島健悟、高橋翔
  • Journal Title: 日本小児アレルギー学会誌 Volume: ２９（３） Pages: 312-317
  • NAID: 130005104357
  • Peer Reviewed
• [Presentation] 生物統計学統計家とのコミュニケーション (2015)
  • Author(s): 佐藤 泰憲
  • Organizer: 第130回 関東連合産婦人科学術集会
  • Place of Presentation: 幕張メッセ国際会議場（千葉県・千葉市）
  • Year and Date: 2015-10-24
  • Invited
• [Presentation] 統計の基礎プロバビリティーカーブ, カットオフとは？ (2015)
  • Author(s): 佐藤 泰憲
  • Organizer: 第64回日本アレルギー学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都・港区）
  • Year and Date: 2015-05-26
  • Invited
• [Presentation] これだけは知っておきたい！生物統計と臨床研究の基本 (2014)
  • Author(s): 佐藤泰憲
  • Organizer: 第51回日本小児アレルギー学会
  • Place of Presentation: 三重県四日市市文化会館
  • Year and Date: 2014-11-08 – 2014-11-09
  • Invited
• [Presentation] nformation criterion for Firth-type penalized partial likelihood in Cox regression. (2014)
  • Author(s): Nagashima K, Sato Y
  • Organizer: The 27th International Biometric Conference
  • Place of Presentation: Firenze Fiera, Italy.
  • Year and Date: 2014-07-06 – 2014-07-11
• [Remarks] 千葉大学大学院医学研究院グローバル臨床試験学 研究紹介
  • URL: http://www.m.chiba-u.jp/class/biostat/research/index.html