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Development of measles virus vector-based vaccine against highly pathogenic avian influenza virus

Research Project

Project/Area Number 26870147
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Virology
Research InstitutionThe University of Tokyo

Principal Investigator

Fujiyuki Tomoko  東京大学, 医科学研究所, 助教 (50610630)

Research Collaborator KAI Chieko  東京大学, 医科学研究所, 教授 (10167330)
YONEDA Misako  東京大学, 医科学研究所, 准教授 (40361620)
KOHARA Michinori  東京都医学総合研究所, ゲノム医科学研究分野, シニア研究員 (10250218)
KIDA Hiroshi  北海道大学, 人獣共通感染症リサーチセンター, 特任教授 (10109506)
HATTORI Shosaku  東京大学, 医科学研究所, 特任研究員 (00164864)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords高病原性鳥インフルエンザウイルス / 麻疹ウイルス / カニクイザル / 感染モデル / 発症防御 / ワクチン / ベクター / 組換えウイルス / ウイルスベクター / H5N1
Outline of Final Research Achievements

We generated recombinant measles virus (rMV) expressing the hemagglutinin (HA) protein of HPAIV (H5), and examined protective efficacy of the candidate vaccine in the monkey infection model by the challenge with a HPAIV (H5N1). Cynomolgus monkeys inoculated with the candidate vaccine produced anti-H5 HA antibodies and recovered earlier from influenza symptoms than unvaccinated monkeys after the challenge with the HPAIV strain. In addition, vaccination tended to suppress viral shedding. Moreover, even in monkeys possessing pre-existing anti-MV antibodies, the vaccination with the candidate induced the production of antibodies against H5 HA. These results suggest that the rMV expressing H5 HA is a good candidate vaccine against HPAIV infection to reduce disease severity.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Presentation (6 results)

  • [Presentation] 麻疹ウイルスベクターを利用した高病原性鳥インフルエンザウイルスワクチンの霊長類感染モデルにおける効果2016

    • Author(s)
      藤幸知子、堀江亮、米田美佐子、倉石武、安井文彦、権賢貞、池田房子、宗片圭祐、石井美穂、木曽有里、佐藤宏樹、服部正策、喜田宏、小原道法、甲斐知恵子
    • Organizer
      第63回日本実験動物学会
    • Place of Presentation
      川崎
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Efficacy of recombinant measles virus expressing highly pathogenic avian influenza virus antigen in non-human primate model2015

    • Author(s)
      Tomoko Fujiyuki, Ryo Horie, Misako Yoneda, Takeshi Kuraishim Fumihiko Yasui, Hyun-jeoung Kwon, Fusako Ikeda, Keisuke Munekata, Miho Ishii, Yuri Kiso, Mio Omi, Hiroki Sato, Hiroshi Kida, Shosaku Hattori, Michinori Kohara, Chieko Kai.
    • Organizer
      第63回日本ウイルス学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
  • [Presentation] H5N1高病原性鳥インフルエンザ組換えワクチニアワクチン単回接種による免疫長期持続作用機序の解析2014

    • Author(s)
      安井文彦、宗片圭祐、倉石武、服部正策、藤幸知子、米田美佐子、迫田義博、喜田宏、甲斐知恵子、小原道法
    • Organizer
      第62回日本ウイルス学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Attenuated recombinant measles virus expressing highly pathogenic avian influenza virus (HPAIV) antigen is protective against HPAIV challenge in cynomolgus monkeys2014

    • Author(s)
      Tomoko Fujiyuki, Ryo Horie, Misako Yoneda, Takeshi Kuraishi, Fumihiko Yasui, Keisuke Munekata, Shosaku Hattori, Hiroshi Kida, Michinori Kohara, Chieko Kai.
    • Organizer
      XVIth International Congress of Virology
    • Place of Presentation
      カナダ、モントリオール
    • Year and Date
      2014-07-27 – 2014-08-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 霊長類感染モデルを用いた高病原性鳥インフルエンザウイルス抗原発現組換え麻疹ウイルスの防御効果の解析2014

    • Author(s)
      藤幸知子、堀江亮、米田美佐子、倉石武、安井文彦、宗片圭祐、池田房子、木曽有里、権賢貞、石井美穂、佐藤宏樹、服部正策、喜田宏、小原道法、甲斐知恵子
    • Organizer
      第61回日本実験動物学会
    • Place of Presentation
      札幌
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Macaque models of highly pathogenic avian influenza virus infection using a wild water bird-derived strain.2014

    • Author(s)
      Tomoko Fujiyuki, Misako Yoneda, Fumihiko Yasui, Takeshi Kuraishi, Shosaku Hattori, Hyun-jeong Kwon, Keisuike Munekata, Yuri Kiso, Hiroshi Kida, Michinori Kohara, Chieko Kai.
    • Organizer
      第14回東京大学生命科学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-04-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-12-17  

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