The basic study that aimed at elucidation of pathological mechanism and new regulation techniques of the intractable oral mucosa disease
| Project/Area Number |
26870170
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Surgical dentistry
Morphological basic dentistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 口腔扁平苔癬 / PD-1陽性T細胞 / 基底細胞 / PD-L1 / 紅色型 / 白色型 / 金属アレルギー / 口腔白板症 / 癌化 / 臨床的因子 / 臨床的検討 |
|---|
| Outline of Final Research Achievements |
Oral lichen planus (OLP) is a common chronic inflammatory mucosal disease. While the pathophysiology of OLP is not clearly understood, it is characterized by a dense subepithelial infiltration of activated CD4 and CD8 T cells and a hydropic degeneration of the basal epithelial cells (keratinocytes). The costimulatory signals which can be either positive or negative and the large amount of cytokines released from various cells contribute to the regulation of T cell immune responses.
We observed that PD-1 was expressed on subepithelial infiltrating CD3 positve T cells in OLP lesion. In addition, PD-L1 expression was induced on the keratinocytes located close to the infiltrates. These results suggested that PD-1 on T cells - PD-L1 on keratinocytes interaction contributed to the regulation of immune responses in OLP lesion.
|
Report
(5 results)
Research Products
(26 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 診断に苦慮した腸管ベーチェット病疑いの1例2014
Author(s)
津島 文彦, 桜井 仁亨, 松本 佳奈子, 上杉 篤史, 佐藤 昌, 尾田 誠一郎, 原田 浩之
Organizer
第24回日本口腔内科学会・第27回日本口腔診断学会 合同学術大会
Place of Presentation
福岡，九州大学医学部百年講堂
Year and Date
2014-09-19 – 2014-09-20
Related Report
-
[Presentation] 上下顎歯肉に生じた開口部形質細胞症の1例2014
Author(s)
上杉 篤史, 櫻井 仁亨, 津島 文彦, 佐藤 昌, 松本 佳奈子, 佐藤 潔, 尾田 誠一郎, 原田 浩之
Organizer
第24回日本口腔内科学会・第27回日本口腔診断学会 合同学術大会
Place of Presentation
福岡，九州大学医学部百年講堂
Year and Date
2014-09-19 – 2014-09-20
Related Report
-
-
