| Project/Area Number |
26870171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
Laboratory medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | インスリン抵抗性 / 血管内皮細胞 / 動脈硬化 / 2型糖尿病 |
|---|
| Outline of Final Research Achievements |
We explored forkhead transcription factors-dependent genes in macrophages and endothelial cells, using macrophage-specific FoxO1/3a/4-knockout mice and FoxO1-constitutive-active adenovirus, respectively. FoxO1/3a/4 ablation in macrophages markedly inhibited LPS-induced inflammatory responses. In EC, FoxO1 overexpression strongly induced lipocalin-2 expression.
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