Investigation of the transcription factors to control the function and development of basophils.

• Project/Area Number: 26870172
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology; Immunology
• Research Institution: Chiba University
• Principal Investigator: NINOMIYA Kazusige 千葉大学, 医学(系)研究科(研究院), 特任助教 (20706999)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 転写因子 / アレルギー / 免疫 / 寄生虫感染症 / 免疫学 / アレルギー・免疫関連疾患

Outline of Final Research Achievements

There are many patients suffering from various allergic diseases in developed countries. The effective drugs are desired to improve the quality of life of the patients. Recently, it has been revealed that basophils play an important role in develop and maintenance of these allergic diseases. In this study, we identified the transcription factor GATA-1 controls the differentiation and function of basophils. This study opens up the possibility that GATA-1 may be a therapeutic target for allergic diseases.

Research Products

• [Journal Article] Basophils trigger fibroblast activation in cardiac allograft fibrosis development. (2016)
  • Author(s): Schiechl G, Hermann FJ, Rodriguez Gomez M, Kutzi S, Schmidbauer K, Talke Y, Neumayer S, Goebel N, Renner K, Bruhl H, Karasuyama H, Obata-Ninomiya K, Utpatel K, Evert M, Hirt SW, Geissler EK, Fichtner-Feigl S, Mack M.
  • Journal Title: American Journal of Transplandation Volume: 印刷中 Issue: 9 Pages: 2574-2588
  • DOI: 10.1111/ajt.13764
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. (2015)
  • Author(s): Tsai, S-H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada, Y., Takeda, A., Yoshikawa, S., Obata-Ninomiya, K., Kurashima, Y., Sato, S., Umemoto, E., Kiyono, H., Karasuyama, H. and Takeda, K.
  • Journal Title: Immunity Volume: 42(2) Issue: 2 Pages: 279-293
  • DOI: 10.1016/j.immuni.2015.01.015
  • Peer Reviewed / Open Access
• [Journal Article] The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway. (2015)
  • Author(s): Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K, Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.
  • Journal Title: Immunity Volume: 42(2) Issue: 2 Pages: 294-308
  • DOI: 10.1016/j.immuni.2015.01.016
  • Peer Reviewed / Open Access
• [Journal Article] Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. (2014)
  • Author(s): Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, DJ., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K. and Nakayama, T.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 111(35) Issue: 35 Pages: 12829-34
  • DOI: 10.1073/pnas.1321245111
  • Peer Reviewed / Open Access
• [Presentation] Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. (2015)
  • Author(s): Endo, Y., Asou, H. K., Matsugae, N., Ninomiya, K., Yamamoto, T., and Nakayama, T.
  • Organizer: 第44回日本免疫学会総会・学術集会
  • Place of Presentation: 札幌コンベンションセンター(北海道・札幌市)
  • Year and Date: 2015-11-18
• [Presentation] GATA-1 controls the generation and function of basophils. (2014)
  • Author(s): Obata-Ninomiya, K., Nei, Y., Tsutsui, H., Ishiwata, K., Miyasaka, M., Matsumoto, K., Nakae, S., Kanuka, H., Inase, N., Nakayama, T., and Karasuyama, H.
  • Organizer: 第43回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館、京都府京都市
  • Year and Date: 2014-12-12
• [Presentation] The trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. (2014)
  • Author(s): Watanabe, Y., Onodera, A., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Morimoto, Y., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K., and Nakayama, T.
  • Organizer: 第43回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館、京都府京都市
  • Year and Date: 2014-12-12
• [Remarks] 千葉大学大学院医学研究院免疫発生学ホームページ
  • URL: http://www.m.chiba-u.ac.jp/class/meneki/
• [Remarks] 千葉大学大学院医学研究院免疫発生学
  • URL: http://www.m.chiba-u.ac.jp/class/meneki/