Effect of functional impairment of tongue on swallowing
| Project/Area Number |
26870207
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
Prosthodontics/ Dental materials science and
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 嚥下 / 舌下神経 / 嚥下圧 / 筋活動電位 / 反回神経 / 咽頭圧 / 食道圧 / 筋電図 / ラット |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the role of the hypoglossal nerve on swallowing movement. We measured swallowing pressure at the oropharynx (OP), upper esophageal sphincter (UES), and cervical esophagus (CE) in anesthetized rats. A swallow was evoked by mechanical stimulation to the larynx. The swallow was identified by activation of the suprahyoid and thyrohyoid muscles. Following bilateral hypoglossal nerve transection (Bi-12Nx), the oropharyngeal pressure during swallowing was significantly decreased than that before transection. The oropharyngeal pressure during swallowing following Bi-12Nx was significantly increased by covering the hard and soft palates with dental material. These results suggest that the hypoglossal nerve play a crucial role in the generation of oropharyngeal pressure during swallowing, and that covering the palates with dental material may reverse the impared swallowing function after damage of hypoglossal nerves.
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Report
(4 results)
Research Products
(6 results)
