| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The aim of this study was to investigate the role of the hypoglossal nerve on swallowing movement. We measured swallowing pressure at the oropharynx (OP), upper esophageal sphincter (UES), and cervical esophagus (CE) in anesthetized rats. A swallow was evoked by mechanical stimulation to the larynx. The swallow was identified by activation of the suprahyoid and thyrohyoid muscles. Following bilateral hypoglossal nerve transection (Bi-12Nx), the oropharyngeal pressure during swallowing was significantly decreased than that before transection. The oropharyngeal pressure during swallowing following Bi-12Nx was significantly increased by covering the hard and soft palates with dental material. These results suggest that the hypoglossal nerve play a crucial role in the generation of oropharyngeal pressure during swallowing, and that covering the palates with dental material may reverse the impared swallowing function after damage of hypoglossal nerves.
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