| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Our meta-analyses which aimed to assess the ability of genetic testing for type 2 diabetes mellitus succeeded in establishing the following quantitative evidence. In conclusion, using only diabetes-susceptible genes would be almost impossible to detect individuals at high risk of diabetes. (1) The dose-response curve between cumulative risk alleles (RAs) and risk of diabetes indicated that the increase in the diabetes risk in relation to cumulative RAs was weakened as the number of RAs carried increased. (2) Diagnostic value of genetic testing based on GWAS was considered minimal, which was concluded from pooled positive likelihood ratio and negative likelihood ratio was 1.32 and 0.76, respectively. (3) Pooled OR of incident diabetes for carrying one RA was 1.10, which approximately corresponded to one for the increase in body weight by 2 kg.
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