A comprehensive analysis of ion transport molecule for the physiological role in the cochlear epithelial layer.
| Project/Area Number |
26870210
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
General physiology
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| Research Institution | Niigata University |
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Principal Investigator |
OGATA GENKI 新潟大学, 研究推進機構, 助教 (80452829)
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| Research Collaborator |
HIBINO Hiroshi 新潟大学, 医歯学系, 教授 (70314317)
NIN Fumiaki 新潟大学, 医歯学系, 准教授 (80644905)
NAGAMORI Shushi 大阪大学, 医学系研究科, 准教授 (90467572)
YOSHIDA Takamasa 新潟大学, 医歯学総合研究科, 大学院生
UETSUKA Satoru 新潟大学, 医歯学総合研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 蝸牛 / 血管条 / 内リンパ液 / チャネル / トランスポータ / 内耳蝸牛 / イオンチャネル / 聴覚 / カリウムイオン / 質量分析 |
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| Outline of Final Research Achievements |
Endolymph, which is the fluid contained in the inner ear, always shows the high potential of +80 mV. The decrease of endocochlear potential cause the hearing loss. This high potential is dependent on both of the potential and the ionic concentration behavior of the stria vascularis, which consists of two layer of epithelial tissues, the inner and the outer layer. In this study, we identified 104 ionic transport molecules which contribute to the ionic behavior of the stria vascularis. In addition, we identified that the sodium ionic transportation of the outer layer of the stria vascularis is important for maintaining the endocochlear potential by using the electrophysiological experiments and the computer simulation analysis.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea.2015
Author(s)
Uetsuka S, Ogata G, Nagamori S, Isozumi N, Nin F, Yoshida T, Komune S, Kitahara T, Kikkawa Y, Inohara H, Kanai Y, Hibino H.
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Journal Title
Eur J Neurosci.
Volume: 42
Issue: 3
Pages: 1984-2002
DOI
Related Report
Peer Reviewed
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[Presentation] Proteomic analysis of membrane transport systems of the epithelial tissue in the mammalian cochlea.2015
Author(s)
Satoru Uetsuka, Genki Ogata, Shushi Nagamori, Noriyoshi Isozumi, Fumiaki Nin, Takamasa Yoshida, Tadashi Kitahara, Yoshiaki Kikkawa, Hidenori Inohara, Yoshikatsu Kanai, Hiroshi Hibino.
Organizer
Oral presentation: 30th Politzer Society Meeting.
Place of Presentation
Toki Messe, Niigata.
Year and Date
2015-07-01
Related Report
Int'l Joint Research
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[Presentation] The mechanism underlying the potassium transport of the lateral wall in the cochlea.2015
Author(s)
Takamasa Yoshida, Fumiaki Nin, Naoko Adachi, Genki Ogata, Satoru Uetsuka, Mitsuo Sato, Hidenori Inohara, Yasuo Hisa, Shizuo Komune, Yoshihisa Kurachi, Hiroshi Hibino.
Organizer
Oral presentation: 30th Politzer Society Meeting.
Place of Presentation
Toki Messe, Niigata.
Year and Date
2015-07-01
Related Report
Int'l Joint Research
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[Presentation] 内耳の特殊体液の恒常性が立脚する上皮イオン輸送の分子構築の解析2015
Author(s)
上塚 学, 緒方 元気, 永森 收志, 五十棲 規嘉, 吉田 崇正, 任 書晃, 北原 糺, 吉川 欣亮, 猪原 秀典, 金井 好克, 日比野 浩
Organizer
第88回 日本薬理学会年会
Place of Presentation
名古屋国際会議場 名古屋市
Year and Date
2015-03-18 – 2015-03-20
Related Report
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[Presentation] 内耳の特殊体液の恒常性が立脚する上皮イオン輸送の分子構築の解析2014
Author(s)
上塚 学, 緒方 元気, 永森 收志, 五十棲 規嘉, 吉田 崇正, 任 書晃, 北原 糺, 吉川 欣亮, 猪原 秀典, 金井 好克, 日比野 浩
Organizer
第65回日本薬理学会北部会
Place of Presentation
コラッセふくしま 福島市
Year and Date
2014-09-26 – 2014-09-27
Related Report
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