Longitudinal study of progression and improvement factors of chronic kidney disease using health checkup cohort

• Project/Area Number: 26870218
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health; Epidemiology and preventive medicine
• Research Institution: Kanazawa University
• Principal Investigator: Toyama Tadashi 金沢大学, 附属病院, 特任助教 (50624871)
• Research Collaborator: WADA Takashi 金沢大学, 医学系, 教授 (40334784) ; FURUICHI Kengo 金沢大学, 附属病院, 准教授 (50432125)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 臨床疫学 / 尿酸 / 慢性腎臓病 / 高尿酸血症 / 生活習慣病 / 予防医学

Outline of Final Research Achievements

A longitudinal study was conducted for those who received a medical examination from 1998 to 2007 on the relationships between serum uric acid (SUA) and the development of chronic kidney disease (CKD). In a study with eGFR less than 60 mL /min/1.73m2 as an outcome, the risk was high in the group with SUA 6 mg/dL or higher, compared to the group with SUA 4 to 4.9 mg/dL in men. The same study was done for women, but no obvious trend was observed. On the other hand, in a study with proteinuria 1+ or more as an outcome, the risk is higher in women with SUA 6 mg/dL or higher than the group with SUA less than 4 mg/dL, and an obvious trend was not observed in men.

Research Products

• [Journal Article] Relationship between Serum Uric Acid Levels and Chronic Kidney Disease in a Japanese Cohort with Normal or Mildly Reduced Kidney Function. (2015)
  • Author(s): Toyama T, Furuichi K, Shimizu M, Hara A, Iwata Y, Sakai N, Perkovic V, Kobayashi M, Mano T, Kaneko S, Wada T.
  • Journal Title: PLoS One. Volume: 10 Issue: 9 Pages: e0137449-e0137449
  • DOI: 10.1371/journal.pone.0137449
  • NAID: 120005680030
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Treatment and impact of dyslipidemia in diabetic nephropathy. (2014)
  • Author(s): Toyama T, Shimizu M, Furuichi K, Kaneko S, Wada T.
  • Journal Title: Clin Exp Nephrol Volume: - Issue: 2 Pages: 201-5
  • DOI: 10.1007/s10157-013-0898-1
  • NAID: 120005349173
  • Peer Reviewed / Open Access
• [Presentation] Hyperuricemia As A Risk Factor For Proteinuria In Japanese General Population (2016)
  • Author(s): Tadashi Toyama, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Miho Shimizu, Kengo Furuichi, Takashi Wada
  • Organizer: ASN Kidney Week 2016
  • Place of Presentation: シカゴ（アメリカ）
  • Year and Date: 2016-11-18
  • Int'l Joint Research
• [Presentation] HYPERURICEMIA AS A RISK FACTOR FOR THE DEVELOPMENT OF PROTEINURIA: AN ANALYSIS OF GENERAL POPULATON COHORT. (2016)
  • Author(s): Tadashi Toyama, Kengo Furuichi, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Miho Shimizu, Takashi Wada
  • Organizer: APCN/ANZSN 2016
  • Place of Presentation: パース（オーストラリア）
  • Year and Date: 2016-09-18
  • Int'l Joint Research
• [Presentation] 一般住民における蛋白尿発症のリスク因子としての高尿酸血症 (2016)
  • Author(s): 遠山直志,北島信治,原章規,岩田恭宜,坂井宣彦,清水美保,古市賢吾,和田隆志
  • Organizer: 第５９回 日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-06-19
  • Int'l Joint Research
• [Presentation] 一般住民における蛋白尿発症のリスク因子としての高尿酸血症 (2016)
  • Author(s): 遠山直志、北島信治、原章規、岩田恭宜、坂井宣彦、清水美保、古市賢吾、和田隆志
  • Organizer: 日本腎臓学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-06-19
• [Book] 尿酸と血糖2016年4月号 Vol.2 no.2 (2016)
  • Author(s): 遠山直志、和田隆志
  • Total Pages: 56
  • Publisher: 先端医学社
• [Book] C.全身性疾患と腎障害 1.糖尿病性腎症における脂質代謝異常 Annual Review 2015腎臓 (2015)
  • Author(s): 遠山直志,和田隆志
  • Total Pages: 3
  • Publisher: 中外医学社