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Comprehensive analysis of biomarkers relating to the immune tolerance and developing the prognosis of the tolerance

Research Project

Project/Area Number 26870244
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Pediatrics
Research InstitutionGifu University

Principal Investigator

Kawamoto Norio  岐阜大学, 医学部附属病院, 助教 (50397337)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords経口免疫療法 / カゼイン
Outline of Final Research Achievements

IgE-mediated reactions are risk of oral immunotherapy (OIT), while T cell reactions seem to be necessary for desensitization. We developed novel hydrolyzed casein, which is designed to digest IgE epitopes and can induce a lymphocyte response and performed the OIT. Thirteen participants with cow's milk allergy were enrolled, and ten have been successively increased the threshold for casein after escalation phase. Cytokines produced from peripheral mononuclear cell stimulated by casein were measured comprehensively by bead-based multiple-proteins quantification system. We used the samples of tree time points consisted by before the escalation phase, after the escalation phase and after the maintenance phase. We could observe no significant difference in these cytokines. However, IL-4/IL-12(p70) ratio showed significant decrease according to the time course, indicating the possible shift toward to Th1 from Th2. Further investigation may needed with larger population.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2015

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Efficacy of slow oral immunotherapy with novel hydrolyzed milk casein2015

    • Author(s)
      Norio Kawamoto, Hideo Kaneko, Minako Kawamoto, Hidenori Ohnishi, Eiko Matsui, Takahide Teramoto, Zenichiro Kato, Toshiyuki Fukao, Hiroshi Ueno, Taku Nakano, Naomi Kondo.
    • Organizer
      第52回日本小児アレルギー学会 International Pediatric Allergy Symposia
    • Place of Presentation
      奈良
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 牛乳アレルギー患者に対する抗原改変カゼインを用いた緩徐法による経口免疫療法の試み2015

    • Author(s)
      川本典生, 金子英雄, 川本美奈子, 大西秀典, 松井永子, 寺本貴英, 加藤善一郎, 深尾敏幸, 上野宏, 中埜拓, 近藤直実
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗原改変カゼインを用いた緩徐法による経口免疫療法の試み2015

    • Author(s)
      川本典生, 金子英雄, 川本美奈子, 大西秀典, 松井永子, 寺本貴英, 加藤善一郎, 深尾敏幸, 上野宏, 中埜拓, 近藤直実
    • Organizer
      第67回東海小児アレルギー談話会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-28
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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