The elucidation of the localization mechanism of RNP to the mitotic chromosomes by using the virus
| Project/Area Number |
26870286
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
Molecular biology
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| Research Institution | Osaka Dental University |
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Principal Investigator |
HIRAI Yuya 大阪歯科大学, 歯学部, 助教 (90710369)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 分裂期染色体 / BDV / RNP / RBMX / 超解像顕微鏡法 |
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| Outline of Final Research Achievements |
In this research project, I aimed to reveal the localization mechanism of Borna disease virus (BDV) RNP, the complex of RNA and proteins, to the mitotic chromosomes. As a result, I showed that (1) the form of BDV RNP was different between in interphase and in mitotic phase, (2) the localization of BDV RNP to the mitotic chromosomes was regulated by the interaction with certain proteins, or the disruption of a nuclear envelope in the cell cycle. It is expected that these results explain the fundamental localization mechanism of RNP to the mitotic chromosomes.
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Report
(4 results)
Research Products
(12 results)
