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Restroration of gait function by using brain and periheral nerve stimulation in central nervous disorder

Research Project

Project/Area Number 26870321
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Rehabilitation science/Welfare engineering
Research InstitutionHokkaido University (2016)
Kyoto University (2014-2015)

Principal Investigator

Koganemaru Satoko  北海道大学, 大学病院, 助教 (40579059)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsリハビリテーション / 歩行機能 / 非侵襲的脳刺激 / 末梢神経筋刺激 / 頚頭蓋直流電流刺激 / 経頭蓋直流電流刺激 / 歩行訓練 / 歩行 / 脳卒中 / 末梢神経筋電気刺激
Outline of Final Research Achievements

In this study, we aimed to activate the remaining function of the impaired nerve pathway by a new method using combined central and peripheral nerve stimulation in patients with lower limb dysfunction caused by neurological disorders, and newly activate the compensatory pathway. In addition to reconstructing the function, we revealed the plastic change in the brain. As a result of this study, the recovery of gait function became possible in patients with chronic stroke hemiplegia.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] Two is More Than One: How to Combine Brain Stimulation Rehabilitative Training for Functional Recovery?2016

    • Author(s)
      Koganemaru S, Fukuyama H, Mima T.
    • Journal Title

      Front Syst Neurosci.

      Volume: 9 Pages: 154-154

    • DOI

      10.3389/fnsys.2015.00154

    • NAID

      120005947022

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neurophysiological measurements of affected and unaffected motor cortex from a cross-sectional, multi-center individual stroke patient data analysis study.2016

    • Author(s)
      Simis M, Di Lazzaro V, Kirton A, Pennisi G, Bella R, Kim YH, Takeuchi N, Khedr EM, Rogers LM, Harvey R, Koganemaru S, Turman B, Tarlac S, Gagliardi RJ, Fregni F.
    • Journal Title

      Neurophysiol Clin.

      Volume: 46 Issue: 1 Pages: 53-61

    • DOI

      10.1016/j.neucli.2016.01.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Static magnetic field can transiently alter the human intracortical inhibitory system.2015

    • Author(s)
      Nojima I, Koganemaru S, Fukuyama H, Mima T.
    • Journal Title

      Clin Neurophysiol.

      Volume: 126 Issue: 12 Pages: 2314-9

    • DOI

      10.1016/j.clinph.2015.01.030

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Action observation with kinesthetic illusion can produce human motor plasticity.2015

    • Author(s)
      Nojima I, Koganemaru S, Kawamata T, Fukuyama H, Mima T.
    • Journal Title

      Eur J Neurosci.

      Volume: 41 Issue: 12 Pages: 1614-23

    • DOI

      10.1111/ejn.12921

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 非侵襲的脳刺激による課題特異的神経可塑性の誘導とリハビリテーションへの応用2017

    • Author(s)
      小金丸聡子
    • Organizer
      平成28年度日本リハビリテーション医学会専門医・臨床認定医生涯教育研修会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2017-03-04
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 経頭蓋律動性脳刺激がヒト歩行に与える影響2017

    • Author(s)
      小金丸聡子、三上佑介、美馬達哉
    • Organizer
      第3回京都リハビリテーション医学研究会学術集会
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2017-02-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Alteration of corticospinal excitability induced by gait-rhythm based oscillatory brain stimulation2016

    • Author(s)
      小金丸聡子
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Human walking entrained by brain alternating current stimulation2015

    • Author(s)
      Koganemaru S
    • Organizer
      Society for neuroscience 2015
    • Place of Presentation
      シカゴ、USA
    • Year and Date
      2015-10-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Efficient strategy for combination of brain stimulation and rehabilitation for post-stroke recovery2015

    • Author(s)
      小金丸聡子
    • Organizer
      第40回日本脳卒中学会
    • Place of Presentation
      広島
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 周期性運動に連動した非侵襲的律動性脳刺激と脳活動変化2014

    • Author(s)
      小金丸聡子
    • Organizer
      第37回日本神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 経頭蓋的徐波律動刺激(tSOS)による歩行のニューロリハビリ2014

    • Author(s)
      小金丸聡子
    • Organizer
      2014年神経オシレーションカンファレンス
    • Place of Presentation
      岡崎
    • Year and Date
      2014-07-17
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Gait-specific plasticity in corticospinal excitability induced by rhythmic brain stimulation2014

    • Author(s)
      小金丸 聡子
    • Organizer
      第51回日本リハビリテーション医学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-06-05
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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