Analysis of a novel molecular mechanism on apoptosis regulation of FA proteins
| Project/Area Number |
26870356
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
Cell biology
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| Research Institution | Kobe University |
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Principal Investigator |
SAKAI Wataru 神戸大学, バイオシグナル総合研究センター, 助教 (70526251)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ファンコニ貧血 / アポトーシス / DNA損傷応答 / 細胞死 / FANCD2 |
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| Outline of Final Research Achievements |
Fanconi anemia (FA) is rare genetic disorder characterized by genome instability. Molecular mechanism of FA proteins is generally focused on the DNA damage response and repair. However, mechanisms of some FA symptoms are still unknown. In the pilot study, I revealed a novel possibility that a FA protein function in regulation of cell death. In this study, the possibility was verified more detail, and implying that a novel mechanism of FA proteins as a negative regulator of apoptosis in DNA damage independent manner. Furthermore, to explore the novel regulation of FA proteins, I challenged isolation of unknown FA-interaction proteins. The comprehensive screening identified more than 100 candidates as novel FA interacting proteins. Gene ontology analysis showed that about 10% of those candidates belong to a specific pathway, unrelated to classic FA pathway.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] A ten-year follow up of a child with mild case of xeroderma pigmentosum complementation group D diagnosed by whole genome sequencing.2016
Author(s)
Ono R, Masaki T, Mayca Pozo F, Nakazawa Y, Swagemakers SM, Nakano E, Sakai W, Takeuchi S, Kanda F, Ogi T, van der Spek PJ, Sugasawa K, Nishigori C.
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Journal Title
Photodermatol Photoimmunol Photomed.
Volume: 未定
Issue: 4
Pages: 174-180
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein.2015
Author(s)
Syota Matsumoto, Eric S. Fischer, Takeshi Yasuda, Naoshi Dohmae, Shigenori Iwai, Toshio Mori, Ryotaro Nishi, Ken-ichi Yoshino, Wataru Sakai, Fumio Hanaoka, Nicolas H. Thoma, Kaoru Sugasawa
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Journal Title
Nucleic Acids Research
Volume: 3
Issue: 3
Pages: 1700-1713
DOI
Related Report
Peer Reviewed / Open Access
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