| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The host-guest interaction of cyclodextrin (CD) involved in a polymeric network would be controlled by an ultrasound because the energy from the ultrasound can be transferred though the polymeric network. In this study, we investigated preparation of a nano-particle composed of the polymeric network containing CD in response to the ultrasound. The nano-particle was prepared by crosslinking of a chitosan by using a tri-substituted caroboxymethyl beta-CD. A particle composed of beta-CD-grafted chitosan and tripolyphosphate was prepared as a comparison sample to clarify the importance of the network structure. The release experiment with rhodamine 6G revealed that the nano-particle having the CD-containing polymeric network showed a sustained release by the exposure to the ultrasound, which was 4 folds delayed as compared to spontaneous release.
We further successfully prepared nanoparticles composed of CD-grafted chitosan/doxorubicin conjugate.
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