Development of nanogels showing ultrasound-responsivity based on control of the host-guest interaction
Project/Area Number |
26870374
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Polymer/Textile materials
Polymer chemistry
|
Research Institution | Tottori University |
Principal Investigator |
Izawa Hironori 鳥取大学, 工学(系)研究科(研究院), 助教 (50643235)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | キトサン / シクロデキストリン / ドラッグデリバリーシステム / ホスト-ゲスト相互作用制御 |
Outline of Final Research Achievements |
The host-guest interaction of cyclodextrin (CD) involved in a polymeric network would be controlled by an ultrasound because the energy from the ultrasound can be transferred though the polymeric network. In this study, we investigated preparation of a nano-particle composed of the polymeric network containing CD in response to the ultrasound. The nano-particle was prepared by crosslinking of a chitosan by using a tri-substituted caroboxymethyl beta-CD. A particle composed of beta-CD-grafted chitosan and tripolyphosphate was prepared as a comparison sample to clarify the importance of the network structure. The release experiment with rhodamine 6G revealed that the nano-particle having the CD-containing polymeric network showed a sustained release by the exposure to the ultrasound, which was 4 folds delayed as compared to spontaneous release. We further successfully prepared nanoparticles composed of CD-grafted chitosan/doxorubicin conjugate.
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Report
(3 results)
Research Products
(14 results)