| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Apathy is a state without motivation, and defined as diminished or decreased goal-directed behavior. This study aimed to investigate the neural mechanism of apathy using multiple approaches. In a resting-state fMRI analysis for healthy elderly, apathy is associated with executive function, and involved in decreased functional connectivity between lateral prefrontal cortex and basal ganglia. Also, an another experiment revealed that the functional connectivity between basal ganglia and supplemental motor area is related with apathy in healthy elderly. These evidences suggested that multiple frontal-basal ganglia loops are involved in apathy.
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