Neural basis of apathy: multiple MRI approaches

• Project/Area Number: 26870375
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Basic / Social brain science; Experimental psychology
• Research Institution: Shimane University
• Principal Investigator: Onoda Keiichi 島根大学, 医学部, 講師 (60432712)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アパシー / 安静時fMRI / 動機づけ / VBM / 前頭基底核回路

Outline of Final Research Achievements

Apathy is a state without motivation, and defined as diminished or decreased goal-directed behavior. This study aimed to investigate the neural mechanism of apathy using multiple approaches. In a resting-state fMRI analysis for healthy elderly, apathy is associated with executive function, and involved in decreased functional connectivity between lateral prefrontal cortex and basal ganglia. Also, an another experiment revealed that the functional connectivity between basal ganglia and supplemental motor area is related with apathy in healthy elderly. These evidences suggested that multiple frontal-basal ganglia loops are involved in apathy.

Research Products

• [Journal Article] Associations among executive function, cardiorespiratory fitness, and brain network properties in older adults (2017)
  • Author(s): Kawagoe T, Onoda K, Yamaguchi S
  • Journal Title: Frontier in Aging Neurosciece Volume: -
  • NAID: 120006649703
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Theta band transcranial alternating current stimulations modulates network behavior of dorsal anterior cingulate cortex (2017)
  • Author(s): Onoda K, Kawagoe T, Zheng H, Yamaguchi S
  • Journal Title: Sci Rep. Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] Associations among executive function, cardiorespiratory fitness, and brain network properties in older adults (2017)
  • Author(s): Kawagoe T, Onoda K, Yamaguchi S
  • Journal Title: Sci Rep. Volume: - Issue: 1
  • DOI: 10.1038/srep40107
  • NAID: 120006649703
  • Peer Reviewed / Open Access
• [Journal Article] Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices. (2017)
  • Author(s): Yoshimura S, Okamoto Y, Matsunaga M, Onoda K, Okada G, Kunisato Y, Yoshino A, Ueda K, Suzuki SI, Yamawaki S.
  • Journal Title: J Affect Disord Volume: 208 Pages: 610-614
  • DOI: 10.1016/j.jad.2016.10.017
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Effectiveness of Repetitive Transcranial Magnetic Stimulation for Poststroke Apathy Is Associated with Improved Interhemispheric Functional Connectivity (2016)
  • Author(s): Mitaki S, Onoda K, Abe S, Oguro H, Yamaguchi S.
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 25 Issue: 12 Pages: 219-221
  • DOI: 10.1016/j.jstrokecerebrovasdis.2016.05.014
  • Peer Reviewed
• [Journal Article] Neuroanatomic pathways associated with monoaminergic dysregulation after stroke (2016)
  • Author(s): Hama S, Murakami T, Yamashita H, Onoda K, Yamawaki S, Kurisu K.
  • Journal Title: Int J Geriatr Psychiatry Volume: June 1 Issue: 6 Pages: 633-642
  • DOI: 10.1002/gps.4503
  • Peer Reviewed / Open Access
• [Journal Article] Dissociative contributions of the anterior cingulate cortex to apathy and depression: Topological evidence from resting-state functional MRI. (2015)
  • Author(s): Onoda K, Yamaguchi S.
  • Journal Title: Neuropsychologia Volume: 77 Pages: 10-18
  • DOI: 10.1016/j.neuropsychologia.2015.07.030
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gray Matter Volume Changes in the Apathetic Elderly. (2015)
  • Author(s): Yan H, Onoda K, Yamaguchi S.
  • Journal Title: Front Hum Neurosci Volume: 9 Pages: 318-318
  • DOI: 10.3389/fnhum.2015.00318
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] fMRI Study of Social Anxiety during Social Ostracism with and without Emotional Support. (2015)
  • Author(s): Nishiyama Y, Okamoto Y, Kunisato Y, Okada G, Yoshimura S, Kanai Y, Yamamura T, Yoshino A, Jinnin R, Takagaki K, Onoda K, Yamawaki S
  • Journal Title: PLoS One Volume: 10 Issue: 5 Pages: 0127426-0127426
  • DOI: 10.1371/journal.pone.0127426
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 加齢及び認知症における脳機能ネットワークの変化とその応用 (2015)
  • Author(s): 小野田慶一
  • Organizer: 第18回日本薬物脳波学会.
  • Place of Presentation: 和歌山(コガノイ ベイ ホテル)
  • Year and Date: 2015-06-26
• [Presentation] Difference in resting-state neural network for apathy and depression (2015)
  • Author(s): Keiichi Onoda, Shuhei Yamaguchi
  • Organizer: 2015 Institute of Complex Medical Engineering (ICME)
  • Place of Presentation: Okayama (Okayama Convention Center)
  • Year and Date: 2015-06-18
  • Int'l Joint Research
• [Presentation] 加齢に伴う認知・情動機能の変化に関する安静時fMRI研究 (2015)
  • Author(s): 小野田慶一
  • Organizer: Fmθ研究会
  • Place of Presentation: 大阪，住友クラブ
  • Year and Date: 2015-03-07
  • Invited
• [Presentation] 安静時fMRIの基礎 (2015)
  • Author(s): 小野田慶一・山口修平
  • Organizer: 北海道脳卒中勉強会
  • Place of Presentation: 札幌，札幌プリンスホテル
  • Year and Date: 2015-01-17
  • Invited
• [Presentation] 認知症診療を主体とする安静時fMRIの臨床応用 (2015)
  • Author(s): 小野田慶一・山口修平
  • Organizer: 北海道脳卒中勉強会
  • Place of Presentation: 札幌，札幌プリンスホテル
  • Year and Date: 2015-01-17
  • Invited
• [Presentation] 安静時fMRIを用いたアパシーの神経機序の解明 (2014)
  • Author(s): 小野田慶一・山口修平
  • Organizer: NatureHyogo
  • Place of Presentation: 神戸，ラ・スイート神戸ハーバーランド
  • Year and Date: 2014-11-14
• [Presentation] 目標志向的行動の減少と前頭－基底核回路の関連： 高齢者における安静時fMRI研究 (2014)
  • Author(s): 小野田慶一・濱田智津子・山口修平
  • Organizer: 第32回日本生理心理学会
  • Place of Presentation: 筑波，筑波大学
  • Year and Date: 2014-05-17 – 2014-05-18