| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Juvenile hormone is an insect hormone that regulates various physiological mechanisms such as molting and metamorphosis. Therefore, its receptor Methoperen-tolerant (Met) is attracting attention as a target molecule for new insect growth regulators. In this study, we have studied for the purpose of developing a JH antagonist that suppresses function of Met by directly binding.
We synthesized various compounds by organic synthesis and examined their biological activities by precocious metamorphosis-inducing activity test against silkworm larva and the binding test to Met protein of the silkworm. As a result, we found compound NY04 as a novel JH antagonist.
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