Biological function of novel adrenomedullins in teleosts and amphibians: focusing on hematopoietic and immune system

• Project/Area Number: 26870386
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Evolutionary biology; Morphology/Structure
• Research Institution: Okayama University
• Principal Investigator: Maho Ogoshi 岡山大学, 自然科学研究科, 助教 (00527997)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アドレノメデュリン / 造血 / 脊椎動物 / メダカ / ネッタイツメガエル / 比較内分泌学

Outline of Final Research Achievements

We examined the hematopoietic function of novel adrenomedullins in vertebrates. The AM3 gene expression was induced after hemolytic anemia in teleost fish, medaka, suggesting its role in erythropoiesis. In Xenopus tropicalis, AM5 mRNA was detected in the ventral blood island at tailbud stage embryo and was expressed in adult hematopoietic stem cells.

Research Products

• [Journal Article] Effects of environmental salinity on expression of all the adrenomedullin genes suggest their osmoregulatory actions in the medaka, Oryzias latipes (2015)
  • Author(s): Ogoshi M, Kato K, Sakamoto T
  • Journal Title: Zoological Letters Volume: 1 Issue: 1 Pages: 1-7
  • DOI: 10.1186/s40851-015-0012-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Adrenomedullin 5 expresses in the hematopietic tissues in Xenopus tropicalis (2015)
  • Author(s): Ogoshi M, Yamaura S, Aoyagi K, Takeuchi S, Takahashi S
  • Organizer: 第40回日本比較内分泌学会・第37回日本比較生理生化学会合同大会（CompBiol 2015広島大会）
  • Place of Presentation: 広島県広島市
  • Year and Date: 2015-12-11
• [Book] Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, edited by Takei Y., Ando H, Tsutsui K (2016)
  • Author(s): Maho Ogoshi
  • Publisher: Academic Press
• [Book] ホメオスタシスと適応 －恒－、海谷啓之・内山実 共編 (2016)
  • Author(s): 御輿真穂、坂本竜哉
  • Publisher: 裳華房