| Project/Area Number |
26870388
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
Gastroenterology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
UEDA Masashi 岡山大学, 医歯薬学総合研究科, 准教授 (40381967)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 膵がん / イメージング / 膵臓癌 / 分子イメージング / PET / SPECT / 癌特異的タンパク質 / 特異的タンパク質 / 膵がん幹細胞 / 間葉系幹細胞 |
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| Outline of Final Research Achievements |
To develop early diagnostic method of pancreatic cancer, we investigated molecular imaging of pancreatic cancer by targeting cancer stem cell, mesenchymal stem cell, or cancer-specific proteins. As a result of analyzing expression of stem cell markers and the proteins in clinical samples and cell lines, some proteins such as plectin-1, 14-3-3 σ and lipocalin-2 were over-expressed in cancer lesions, while stem cells markers were not expressed enough. Despite of synthesis of a imaging probe targeting 14-3-3σ and injection of the probe in the mouse xenograft model, accumulation of the probe to the tumor was not enough for utilizing the imaging. Further evaluation of binding-capacity of the probe to 14-3-3σ and creation of a probe with an enhanced capability of accumulation in tumor were needed.
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