Pathologic significance of epicardial adipose tissue -evaluation by clinical imaging and histology
| Project/Area Number |
26870395
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
Cardiovascular medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心外膜下脂肪 / 冠動脈硬化症 / 画像診断 |
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| Outline of Final Research Achievements |
The aim of this study was to evaluate the pathologic significance of epicardial adipose tissue (EAT), surrounding the heart, through the comparison of clinical imaging and histology of EAT samples obtained during cardiac surgery. We found the correlation between coronary atherosclerosis on computed tomography and biologic activities of EAT, represented by inflammation and neoangiogenesis on histology. Our results suggest that EAT has the 'diseased ' property as a new bad fat tissue in clinical practice. To further investigate the pathologic impact of EAT, the analyses using molecular imaging and those of inflammatory cytokines are under the process.
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Report
(4 results)
Research Products
(12 results)
