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Eicosapentaenoic acid for browning effect through GPR120

Research Project

Project/Area Number 26870401
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Metabolomics
Research InstitutionHiroshima University

Principal Investigator

Haruya Ohno  広島大学, 医歯薬保健学研究院(医), 助教 (60725894)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords褐色脂肪細胞 / ベージュ脂肪細胞 / GPR120 / 脂肪酸 / 褐色脂肪組織
Outline of Final Research Achievements

We investigated the effect of Eicosapentaenoic acid on brown fat functions through one of its receptor, GPR120. GW9508, a specific GPR120 agonist, elevated brown fat specific genes including Ucp-1 in brown adipocytes. Knockdown of GPR120 or addition of MEK1/2 inhibitors canceled the activating effect of GW9508. Eicosapentaenoic acid might activate brown adipocytes through the GPR120 and MAPK pathway.
Morphological and gene expression analyses in perirenal adipose tissue in pheochromocytoma patients revealed that EHMT1, a histon methyltransferase, might play an important role for developing brown adipocytes in adult human.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Activation of Classical Brown Adipocytes in the Adult Human Perirenal Depot Is Highly Correlated with PRDM16-EHMT1 Complex Expression2015

    • Author(s)
      Gaku Nagano, Haruya Ohno, Kenji Oki, Kazuhiro Kobuke, Tsuguka Shiwa, Masayasu Yoneda, and Nobuoki Kohno
    • Journal Title

      PloS ONE

      Volume: 10 Issue: 3 Pages: e0122584-e0122584

    • DOI

      10.1371/journal.pone.0122584

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] GPR120 agonistは褐色脂肪細胞における熱産生遺伝子の発現を上昇させる2015

    • Author(s)
      森田好美、大野晴也、長野学、米田真康
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] メチル基供与体合成酵素MATIIは褐色脂肪細胞熱産生能を制御する2015

    • Author(s)
      長野学、大野晴也、森田好美、米田真康
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] EHMT1による褐色脂肪細胞の分化と熱産生能の制御2015

    • Author(s)
      大野晴也
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ヒト腎周囲の古典的褐色脂肪細胞は PRDM16/EHMT1 依存的に再誘導される2014

    • Author(s)
      ○長野  学、大野 晴也、森田 好美、沖  健司、米田 真康
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] EHMT1 and the stimulation with elevated catecholamines can reinduce the perirenal brown adipocytes possessing classical features in adult humans2014

    • Author(s)
      G. Nagano, H. Ohno, T. Shiwa, K. Oki, M. Yoneda
    • Organizer
      50th EASD Annual Meeting
    • Place of Presentation
      ウィーン、オーストリア
    • Year and Date
      2014-09-15 – 2014-09-19
    • Related Report
      2014 Research-status Report
  • [Book] Diabetes Frontier 「褐色脂肪細胞の分化とインスリン感受性制御」2015

    • Author(s)
      大野晴也(分担)
    • Total Pages
      5
    • Publisher
      メディカルビュー社
    • Related Report
      2015 Annual Research Report
  • [Book] 医学のあゆみ 「褐色脂肪細胞およびベージュ脂肪細胞の由来」2015

    • Author(s)
      大野晴也(分担)
    • Total Pages
      5
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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