| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Mild traumatic brain injury (mTBI), known such as concussion, is usually harmless injury. However, repetitive mTBI could cause worse outcome in the long-term clinical course, which mechanism is unknown. The purpose of this study is to assess the mechanism of development after repetitive mTBI by animal experiment. Rats underwent two repetitive mTBIs in 3h interval and blood, cerebrospinal fluid (CSF), and brain tissue was taken in pre-determined time points. Interleukin 6 (IL6), known as an inflammatory cytokine, was measured in each sample. Serum IL6 was increased after the first impact, but was not after the second one. Although IL6 level in CSF was not increased after the first impact, it was remarkably increased after the second one. Interestingly, IL6 presentation in the brain tissue, which was assessed by relative increase of IL6 mRNA, showed similar change to that of CSF.
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