Effect of estrogen on tail-hiding behavior in the cold-Mechanism of behavioral thermoregulation in the cold in women-

• Project/Area Number: 26870417
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology); Neurophysiology / General neuroscience
• Research Institution: Nara Women's University (2016-2017); Kochi University (2014-2015)
• Principal Investigator: Uchida Yuki 奈良女子大学, 生活環境科学系, 助教 (50634002)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: エストロゲン / 尾隠し行動 / TRPM8 / TRPA1 / 行動性体温調節 / 島皮質 / メントール / シナモン / 寒冷環境 / シナモアルデヒド / 女性ホルモン / TRP受容体 / 熱放散 / cFos / 脳

Outline of Final Research Achievements

Rats place their tails underneath their body trunks in the cold (tail-hiding behavior). Tail-hiding behavior was used as an indicator of natural thermoregulatory behavior in this study. This study demonstrated that estrogen facilitated thermoregulatory behavior in the cold, and the insula might be involved in the response. Additionally, estrogen modulated thermoregulatory responses via peripheral cold receptors, TRPM8 and TRPA1. The paraventricular nucleus might be involved the increased body temperature mediated TRPM8.

Research Products

• [Journal Article] 中等教育段階を中心とした家庭科学習における情報機器を導入した新たな教材の開発と提案 (2018)
  • Author(s): 佐藤克成, 才脇直樹, 吉田哲也, 内田有希, 佐藤宏介, 岩井大輔
  • Journal Title: 教育システム研究 Volume: 未定
• [Journal Article] Effects of fasting/fasting-related hormones on circadian body temperature rhythm and thermoregulation (2018)
  • Author(s): Kei Nagashima, Ken Tokizawa, Shuri Marui, Yuki Uchida
  • Journal Title: Clinical Autonomic Research Volume: 未定
  • Peer Reviewed / Open Access
• [Journal Article] Regional differences of cFos immunoreactive cells in the preoptic areas in hypothalamus associated with heat and cold responses in mice (2018)
  • Author(s): Yuki Uchida, Keisuke Onishi, Ken Tokizawa, Kei Nagashima
  • Journal Title: Neuroscience Letters Volume: 665 Pages: 130-134
  • DOI: 10.1016/j.neulet.2017.11.053
  • Peer Reviewed
• [Journal Article] Effect of Systemic Estradiol Administration on Circadian Body Temperature and Activity Rhythms in Female Rats. (2017)
  • Author(s): Yuki Uchida, Shuri Marui, Ken Tokizawa, Kei Nagashima
  • Journal Title: Anatomy & Physiology Volume: 7 Issue: 05 Pages: 1-6
  • DOI: 10.4172/2161-0940.1000280
  • Peer Reviewed / Open Access
• [Journal Article] Systemic estradiol administration to ovariectomized rats facilitates thermoregulatory behavior in a cold environment (2017)
  • Author(s): Yuki Uchida, Kei Nagashima, Kazunari Yuri
  • Journal Title: Brain Research Volume: 1670 Pages: 125-134
  • DOI: 10.1016/j.brainres.2017.06.009
  • Peer Reviewed
• [Journal Article] Influence of osmotic stress on thermal perception and thermoregulation in heat is different between sedentary and trained men (2016)
  • Author(s): Ken Tokizawa · Mayumi Matsuda-Nakamura · Yuki Tanaka · Yuki Uchida · Cheng-Hsien Lin · Kei Nagashima
  • Journal Title: Physiology & Behavior Volume: 161 Pages: 66-73
  • DOI: 10.1016/j.physbeh.2016.04.018
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 女性ホルモンと女性の体温調節 ―基礎体温, ホットフラッシュ, 冷え症, 寒冷時調節, 日内リズムとの関連― (2016)
  • Author(s): 内田有希
  • Journal Title: 家政学研究 Volume: 125(63) Pages: 38-41
  • NAID: 40021006787
  • Peer Reviewed
• [Journal Article] 新たな衣服内温度計による女性の就寝中の衣類内温度計測の試み：ケースレポート (2016)
  • Author(s): 内田有希, 永島計, 森本恵子
  • Journal Title: 人間科学研究 Volume: 30(1) Pages: 15-18
  • Peer Reviewed
• [Journal Article] Estrogenic modulation of female thermoregulatory behavior in a cold environment (2016)
  • Author(s): Yuki Uchida, Kei Nagashima, Shuri Marui
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 5 Issue: 1 Pages: 77-80
  • DOI: 10.7600/jpfsm.5.77
  • NAID: 130005138400
  • ISSN: 2186-8123, 2186-8131
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Daily Changes of Body Temperature and Heart Rate are Modulated after Estradiol Depletion in Female Rats (2016)
  • Author(s): Shuri Marui, Yuki Uchida, Kei Nagashima
  • Journal Title: Anatomy & Physiology Volume: 6(1) Issue: 01 Pages: 2-7
  • DOI: 10.4172/2161-0940.1000197
  • Peer Reviewed / Open Access
• [Journal Article] 女性の冷え症～ヒトと動物の基礎研究からの視点～ (2015)
  • Author(s): 内田有希
  • Journal Title: 繊維製品消費科学 Volume: 56(9) Pages: 725-731
  • NAID: 130006336289
  • Peer Reviewed
• [Journal Article] Characteristics of activated neurons in the suprachiasmatic nucleus when mice become hypothermic during fasting and cold exposure (2014)
  • Author(s): Yuki Uchida, Ken Tokizawa, Kei Nagashima
  • Journal Title: Neuroscience Letters Volume: 159 Pages: 177-182
  • DOI: 10.1016/j.jtherbio.2015.03.005
  • Peer Reviewed
• [Presentation] Estrogen replacement enhances insulin-stimulated AS160 activation (2018)
  • Author(s): Mizuho Kawakami, Naoko Nakagi, Miho Nishimura, Yuki Uchida, Akira Takamata, Keiko Morimoto
  • Organizer: 第95回日本生理学会大会
• [Presentation] Effect of estradiol on energy intake under chronic psychosocial stress in ovariectomized rats (2018)
  • Author(s): Miho Nishimura, Sayaka Nishihara, Mariko Kawahara, Mizuho Kawakami, Yuki Uchida, Akira Takamata, Keiko Morimoto
  • Organizer: 第95回日本生理学会大会
• [Presentation] Effect of estradiol administration on thermoregulatory responses induced by application of cinnamaldehyde in ovariectomized rats (2018)
  • Author(s): Yuki Uchida, Koyuki Atsumi
  • Organizer: 第95回日本生理学会大会
• [Presentation] 雌ラットにおけるシナモアルデヒド塗布時の体温調節反応に対するエストラジオール投与の作用 (2017)
  • Author(s): 小柳菜央、渥美小優季、内田有希
  • Organizer: 第45回自律神経生理研究会
• [Presentation] The effect of menstrual cycle phase on foot skin temperature during mild local cooling in young women (2017)
  • Author(s): Yuki Uchida, Koyuki Atsumi
  • Organizer: 第56回生気象学会大会
• [Presentation] Effect of estradiol administration on thermoregulatory responses induced by application of menthol in ovariectomized rats (2017)
  • Author(s): Koyuki Atsumi, Yuki Uchida
  • Organizer: 第56回生気象学会大会
• [Presentation] 雌ラットにおいてエストロゲンがL-メントール刺激時の体温調節反応へ与える影響 (2017)
  • Author(s): 渥美小優季、内田有希
  • Organizer: 温熱生理研究会2017
• [Presentation] Effect of systemic estradiol administration on circadian body temperature and activity rhythms in female rats (2017)
  • Author(s): Yuki Uchida、Shuri Marui、Ken Tokizawa、Kei Nagashima
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: 静岡県浜松市（アクトシティ浜松）
• [Presentation] Estradiol administration modulates thermoregulatory responses induced by application of menthol to the skin of whole trunk in ovariectomized rats (2016)
  • Author(s): Yuki Uchida、Yoji Osako、Kei Nagashima、Kazunari Yuri
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2016-03-24
• [Presentation] 女性が快適に生活するための”温熱生理学” (2016)
  • Author(s): 内田有希
  • Organizer: 人科生命科学系公開シンポジウム 生命の理解からはじまる人間科学
  • Place of Presentation: 早稲田大学所沢キャンパス(埼玉県所沢市)
  • Year and Date: 2016-02-07
• [Presentation] 女性の寒冷時体温調節メカニズムの解明－冷え症の科学－ (2015)
  • Author(s): 内田有希
  • Organizer: 四国５大学連携女性研究者活躍促進シンポジウム2015 多様な人材が輝くグローカル社会へのアプローチ 女性研究者支援を足がかりに
  • Place of Presentation: 徳島大学蔵元キャンパス(徳島県徳島市)
  • Year and Date: 2015-12-08
• [Presentation] Effect of systemic ghrelin administration on tail-hiding behavior and cFos expression of brain areas in rats in the cold (2015)
  • Author(s): Yuki Uchida、Yoji Osako、Kei Nagashima、Kazunari Yuri
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-07-31
• [Presentation] 女性の冷え症～ヒトと動物の基礎研究からの視点～ (2015)
  • Author(s): 内田有希
  • Organizer: 第49回快適性を考えるシンポジウム－女性の健康と快適性（生体機能の性差と性ホルモンの影響）
  • Place of Presentation: キャンパスプラザ京都(京都府京都市)
  • Year and Date: 2015-04-24
• [Presentation] Effect of systemic estradiol administration on tail-hiding behavior and cFos expression of brain areas in female rats in the cold (2015)
  • Author(s): Yuki Uchida、Yoji Osako、Kei Nagashima、Kazunari Yuri
  • Organizer: 第120回日本解剖学会総会・第92回日本生理学会大会合同大会
  • Place of Presentation: 神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-03-22
• [Remarks] Yuki Uchida PhD website
  • URL: https://sites.google.com/site/yukiuchidaphd/
• [Remarks] 奈良女子大学研究者総覧
  • URL: http://koto10.nara-wu.ac.jp/Profiles/16/0001567/profile.html
• [Remarks] Researchmap
  • URL: https://researchmap.jp/uchidayuki/
• [Remarks] J-GLOBAL
  • URL: https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201201088776852374&q=%E5%86%85%E7%94%B0%E6%9C%89%E5%B8%8C&t=0
• [Remarks] ResearchGate
  • URL: https://www.researchgate.net/profile/Yuki_Uchida
• [Remarks] Yuki Uchida, PhD Website
  • URL: https://sites.google.com/site/yukiuchidaphd/
• [Remarks] Yuki Uchida Website
  • URL: http://homepage3.nifty.com/neuroendocrinology/index.html
• [Remarks] Yuki Uchida Website
  • URL: http://homepage3.nifty.com/neuroendocrinology/