| Project/Area Number |
26870420
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
Pathological medical chemistry
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| Research Institution | University of Miyazaki (2015)
Kyushu University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | マクロファージ / 動脈硬化 / マクロピノサイトーシス / 細胞骨格 / 泡沫細胞 |
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| Outline of Final Research Achievements |
Foam cell formation through macropinocytosis in atherosclerosis pathophysiology has been already established. However, detailed mechanism remains to be determined. This study aims to analyze the role of DOCK1/2/5 as Rac activator in foam cell formation. We discovered that the uptake of dextran-FITC was significantly reduced in bone marrow macrophage of DOCK1/2/5 triple knockout mice. Treatment of CPYPP as DOCK 1/2/5 inhibitor in wild type bone marrow macrophage showed the similar result. We found that DOCK1/2/5 function links macropinocytosis formation, suggesting that DOCK1/2/5 participate in foam cell formation. It leads to elucidate their pathogenesis and develop novel therapies.
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