| Project/Area Number |
26870421
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
Immunology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 抗原のクロスプレゼンテーション / 全身性エリテマトーデス / SLE |
|---|
| Outline of Final Research Achievements |
We studied the mechanism of the induction of systemic lupus erythematosus (SLE) mediated via antigen cross-presentation by focusing on stimulator of IFN genes（STING). STING involved in antigen cross-presentation in dendritic cell (DC) in vitro. On the other hand, STING contributed less to antigen cross-presentation in vivo. Further, lupus tissue injury was equally induced in STING-deficient mice as compared to wild-type mice after repeated immunization with exogenous antigen.
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