| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Bone regeneration therapy is key issue in oral and maxillofacial surgery. At present, autogenous bone graft is the gold standard, and we also have reported the benefit of secondary bone graft using particulate cancellous bone and marrow (K Miura, et al.2015). However, this technique has several drawbacks, such as limited quantity of harvested bone and excessive surgical intervention into healthy tissue. So excellent bone regeneration material is expected. During this period, we have demonstrated that lyophilized GAM, which consists of atelocollagen and pDNA encoding effective osteogenic proteins such as BMP4 or Runx2, induced the bone formation (M Umebayashi , et al. 2015). For clinical application of GAM, we will create the more effective biomaterial using nano-bioglass for increasing cell transplantation efficiency, Low Adhesive Scaffold Collagen (LASCol) for faciliating cell migration ability, and low dosage plasmid vectors going forward.
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