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Investigation of microRNA in hair root and hair as a disease marker

Research Project

Project/Area Number 26870444
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Dermatology
Research InstitutionKumamoto University

Principal Investigator

Igata Toshikatsu  熊本大学, 大学院生命科学研究部(医), 助教 (90423673)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsmicroRNA
Outline of Final Research Achievements

In the diseases in which clinically useful diagnostic / therapeutic markers have not yet been found, we measured the root hair / hair microRNA concentration, compared with the normal control group and examined the correlation with clinical symptoms, and found that hair roots / It was examined whether it could be a marker. Significant elevation was observed in dermatomyositis and psoriasis, suggesting the possibility of being used as a biomarker of disease.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2017 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Diagnosis of nail psoriasis: evaluation of nail-derived microRNAs as potential novel biomarkers.2017

    • Author(s)
      Wang Z, Jinnin M, Harada M, Kudo H, Inoue K, Nakayama W, Honda N1, Makino K1, Kajihara I, Fukushima S, Ihn H
    • Journal Title

      European Journal of Dermatology

      Volume: 1 Issue: 1 Pages: 20-27

    • DOI

      10.1684/ejd.2016.2906

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] microRNA level is raised in the hair shafts of patients with dematomyositis in comparison with normal subjects and patients with scleroderma2015

    • Author(s)
      Minami Inoue, Masatoshi Jinnin MD, PhD*, Zhongzhi Wang PhD, Kayo Nakamura MD, Kuniko Inoue MD, PhD, Asako Ichihara MD, PhD, Chikako Moriya MD, PhD, Keisuke Sakai MD, PhD, Satoshi Fukushima MD, PhD andHironobu Ihn MD, PhD
    • Journal Title

      International Journal of Dermatology

      Volume: 24 Issue: 7 Pages: 1-5

    • DOI

      10.1111/ijd.12958

    • Related Report
      2015 Research-status Report
    • Peer Reviewed

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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