Investigation of microRNA in hair root and hair as a disease marker

• Project/Area Number: 26870444
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnostics; Dermatology
• Research Institution: Kumamoto University
• Principal Investigator: Igata Toshikatsu 熊本大学, 大学院生命科学研究部(医), 助教 (90423673)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: microRNA

Outline of Final Research Achievements

In the diseases in which clinically useful diagnostic / therapeutic markers have not yet been found, we measured the root hair / hair microRNA concentration, compared with the normal control group and examined the correlation with clinical symptoms, and found that hair roots / It was examined whether it could be a marker. Significant elevation was observed in dermatomyositis and psoriasis, suggesting the possibility of being used as a biomarker of disease.

Research Products

• [Journal Article] Diagnosis of nail psoriasis: evaluation of nail-derived microRNAs as potential novel biomarkers. (2017)
  • Author(s): Wang Z, Jinnin M, Harada M, Kudo H, Inoue K, Nakayama W, Honda N1, Makino K1, Kajihara I, Fukushima S, Ihn H
  • Journal Title: European Journal of Dermatology Volume: 1 Issue: 1 Pages: 20-27
  • DOI: 10.1684/ejd.2016.2906
  • Peer Reviewed
• [Journal Article] microRNA level is raised in the hair shafts of patients with dematomyositis in comparison with normal subjects and patients with scleroderma (2015)
  • Author(s): Minami Inoue, Masatoshi Jinnin MD, PhD*, Zhongzhi Wang PhD, Kayo Nakamura MD, Kuniko Inoue MD, PhD, Asako Ichihara MD, PhD, Chikako Moriya MD, PhD, Keisuke Sakai MD, PhD, Satoshi Fukushima MD, PhD andHironobu Ihn MD, PhD
  • Journal Title: International Journal of Dermatology Volume: 24 Issue: 7 Pages: 1-5
  • DOI: 10.1111/ijd.12958
  • Peer Reviewed