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Function of AhR and Arnt in Neural Differentiation using Human Neural Progenitor Cell Line.

Research Project

Project/Area Number 26870445
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Risk sciences of radiation and chemicals
Research InstitutionGunma University (2015)
Kumamoto University (2014)

Principal Investigator

Miyazaki Wataru  群馬大学, 医学(系)研究科(研究院), 講師 (90512278)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords環境化学物質 / 脳発達 / 神経分化 / 転写因子
Outline of Final Research Achievements

Several researchers have reported that Environment chemicals, such as dioxins and PCBs, cause adverse effects on human brain development. These effects may be caused through dioxin receptor (AhR)-Arnt complex, but the function of Ahr-Arnt complex on brain development, especially neural differentiation, has not been clarified sufficiently. In this study, we used human fetal brain derived neural progenitor cell line and investigated the function of Ahr-Arnt complex on neural differentiation. Moreover, the relationships between Ahr-Arnt complex and thyroid hormone receptor(TR) were also analyzed.
The knock-down of AhR/Arnt caused the changes of several neural markers. Moreover, AhR and Arnt participated the TR mediated transcription and gene expression.
These results suggested that AhR and Arnt has important roles in human neural differentiation, and also affect the function of several transcriptional factors including TR.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results)

  • [Journal Article] The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the development and function of the blood-brain barrier.2016

    • Author(s)
      Miyazaki W, Fujiwara Y, Katoh T.
    • Journal Title

      NeuroToxicology

      Volume: 52 Pages: 64-71

    • DOI

      10.1016/j.neuro.2015.11.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prenatal exposure to bisphenol A impacts neuronal morphology in the hippocampal CA1 region in developing and aged mice.2015

    • Author(s)
      Kimura E, Matsuyoshi C, Miyazaki W, Benner S, Hosokawa M, Yokoyama K, Kakeyama M, Tohyama C.
    • Journal Title

      Archives of Toxicology

      Volume: in press Issue: 3 Pages: 691-700

    • DOI

      10.1007/s00204-015-1485-x

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence and interannual changes in multiple chemical sensitivity in Japanese workers.2014

    • Author(s)
      Cui X, Lu X, Hiura M, Oda M, Hisada A, Miyazaki W, Omori H, Katoh T.
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 19 Pages: 215-219

    • NAID

      50009145422

    • Related Report
      2014 Research-status Report
    • Peer Reviewed

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Published: 2014-04-04   Modified: 2017-05-10  

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