| Project/Area Number |
26870456
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
Neurosurgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | glioblastoma / 細胞浸潤 / Filamin C / 治療標的 / FLNC / ABCG4 / 予後 |
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| Outline of Final Research Achievements |
In this research, a new prognostic factor related to the prognosis of GBM is searched by using a large public cancer genome database. Then, Filamin C (FLNC) is identified.
Immunohistochemistry using GBM pathologic specimens showed that the FLNC high expression group had a significantly poor prognosis than the FLNC low expression group, and the expression of FLNC also correlated with the GBM grade. It was also shown that suppression of FLNC expression strongly suppresses the invasive ability of GBM cell line cells and the possibility that the infiltration mechanism of GBM centered on FLNC may be a therapeutic target for GBM.
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