| Project/Area Number |
26870459
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
Gastroenterology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Kanmura Shuji 鹿児島大学, 医歯学域附属病院, 講師 (60448561)
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| Research Collaborator |
IDO Akio
KAWABATA Katsuto
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | フルクトース / 腸管維持機構 / タイトジャンクション / 腸管恒常性維持機構 / 腸内細菌数 / 慢性腸炎 / 腸内細菌叢 / 腸炎 / フクルトース / 腸管バリア機能 |
|---|
| Outline of Final Research Achievements |
Fructose is an inverted sugar which is used in popular beverages and recently its consumption has rapidly increased. The excessive intake of fructose is a well known risk factor for obesity and arteriosclerosis, however, it has not been previously evaluated regarding its effect on the intestinal tract. We herein analyzed the impact of fructose on the intestinal barrier function in a experimental colitis model mouse.
The pathology and disease activity index score in a high fructose diet group significantly increased in comparison to a normal diet group, and the tight junction protein expression of occludin significantly decreased in in a high fructose diet. A high concentration of fructose was therefore found to affect the tight junctions of epithelial cells, while also causing the intestinal barrier function to worsen.
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