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CCL8 KOマウスにおけるGVHD消失の分子機構解明に向けた基礎的研究

Research Project

Project/Area Number 26870464
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hematology
Pediatrics
Research InstitutionSapporo Medical University

Principal Investigator

武井 則雄  札幌医科大学, 医学部, 助教 (50523461)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Discontinued (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsGVHD / CCL8 / ZFN / ケモカイン / KOマウス / 移植片対宿主病
Outline of Annual Research Achievements

前年度の研究結果を踏まえ、KOマウスのGVHD発症機構と関連の予想される主要組織適合抗原複合体(MHC)の発現等を含めたphenotype解析の追加実験および、in vitroでのallo recognitionにおけるサイトカイン産生などをWTとKOマウスで比較検証することでKOマウスを用いたGVHDマウスモデル解析におけるGVHD病態変化の要因を探索した。前年度からの本研究成果をまとめ現在論文投稿準備中である。

Report

(2 results)
  • 2015 Annual Research Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Cytoplasmic Fragment of Alcadein α Generated by Regulated Intramembrane Proteolysis Enhances Amyloid β-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage2015

    • Author(s)
      Norio Takei, Yuriko Sobu, Ayano Kimura, Satomi Urano, Yi Piao, Yoichi Araki, Hidenori Taru, Tohru Yamamoto, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki
    • Journal Title

      Journal of Biological Chemistry

      Volume: 290 Issue: 2 Pages: 987-995

    • DOI

      10.1074/jbc.m114.599852

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deficiency of NOX1/nicotinamide adenine dinucleotide phosphate, reduced form oxidase leads to pulmonary vascular remodeling.2014

    • Author(s)
      Iwata K, Ikami K, Matsuno K, Yamashita T, Shiba D, Ibi M, Matsumoto M, Katsuyama M, Cui W, Zhang J, Zhu K, Takei N, Kokai Y, Ohneda O, Yokoyama T, Yabe-Nishimura C.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 34(1) Issue: 1 Pages: 110-119

    • DOI

      10.1161/atvbaha.113.302107

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] CCL8 Deficiency in Host Abolishes Early Mortality in Murine Graft-Versus-Host Disease Model2014

    • Author(s)
      Igarashi K, Takei N, Hori T, Yamamoto M, Kokai Y.
    • Organizer
      56th ASH Annual Meeting and Exposition
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-12-06 – 2014-12-09
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-01-06  

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