A novel treatment for breast cancer using intrinsic magnetized taxol

• Project/Area Number: 26870481
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology; Tumor therapeutics
• Research Institution: Yokohama City University
• Principal Investigator: UMEMURA Masanari 横浜市立大学, 医学部, 助教 (50595353)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 磁性 / 乳がん / がん治療 / ドラッグデリバリー / MRI / タキソール / がん / 磁性化 / パクリタキセル / 創薬 / 医工連携 / 磁性体

Outline of Final Research Achievements

We previously reported a novel magnetic organic compound, N,N’-bis(salicylidene)ethylenediamine iron Fe(Salen), as an anti-cancer agent with intrinsic magnetic property. We identified the magnetic chemical key structure of Fe(salen) generating the magnetic property using Super Photon ring-8 GeV (Spring 8) (RIKEN). Here, we have designed specific covalent linkage of the Fe(Salen), to a commercial available drug, such as PTX. Fe(Salen) serves as a magnetically-responsive scaffold, generating the magnetic property in addition to the classic cytotoxic property of PTX. Our aim is to developing a novel treatment using M-PTX on cancer including breast cancer.

Research Products

• [Journal Article] Magnetic metal complex-conducting copolymer core-shell nanoassemblies for single-drug anticancer platform. (2017)
  • Author(s): Kim J-H, Eguchi H,Umemura M, Sato I, Yamada S, Hoshino Y, Masuda T, Aoki I, Sakurai,YamamotoM, and Ishikawa YK,
  • Journal Title: NPG Asia Materials. Volume: 9 Issue: 3 Pages: e367-e367
  • DOI: 10.1038/am.2017.29
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment. (2017)
  • Author(s): Ohtake M, Umemura M, Sato I, Akimoto T, Oda K, Nagasako A, Kim JH, Fujita T, Yokoyama U, Nakayama T, Hoshino Y, Ishiba M, Tokura S, Hara M, Muramoto T, Yamada S, Masuda T, Aoki I, Takemura Y, Murata H, Eguchi H, Kawahara N, Ishikawa Y.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 42783-42783
  • DOI: 10.1038/srep42783
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles (2016)
  • Author(s): Itaru Sato, Masanari Umemura, Kenji Mitsudo, Hidenobu Fukumura, Jeong-Hwan Kim, Yujiro Hoshino Hideyuki Nakashima, Mitomu Kioi, Rina Nakakaji, Motohiko Sato, Takayuki Fujita, Utako Yokoyama, Satoshi Okumura, Hisashi Oshiro, Haruki Eguchi, Iwai Tohnai and Yoshihiro Ishikawa.
  • Journal Title: Scientific reports Volume: 6 Issue: 1 Pages: 24629-24629
  • DOI: 10.1038/srep24629
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging. (2015)
  • Author(s): Eguchi H, Umemura M, Kurotani R, Fukumura H, Sato I, Kim J-H, Hoshino Y, Lee J, Amemiya N, Sato M, Hirata K, Sigh DJ, Masuda T, Yamamoto M, Urano T, Yoshida K, Tanigaki K, Yamamoto M, Sato M, Inoue S, Aoki I and Ishikawa Y.
  • Journal Title: Sci. Rep. Volume: 5 Issue: 1 Pages: 9194-9194
  • DOI: 10.1038/srep09194
  • Peer Reviewed / Open Access
• [Journal Article] Hyperthermia generated with ferucarbotran (Resovis®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells. (2014)
  • Author(s): Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T Fujita T, Yokoyama U, Okumura S, Feng X, Ito K, Miyajima A, Makino A, Iwai M, Eguchi H, I wai T, and Ishikawa Y.
  • Journal Title: J. Physiol. Sci. Volume: 64 Issue: 3 Pages: 177-183
  • DOI: 10.1007/s12576-014-0309-8
  • Peer Reviewed / Open Access
• [Presentation] Anticancer Nanomagnet-loaded Smart Nano-Ensembles for Magneto-Drug Delivery, MRI, and Hyperthermal Cancer Targeting (2016)
  • Author(s): Kim JH, Eguchi H, Umemura M, and Ishikawa Y.
  • Organizer: AsiaNano
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2016-10-10
  • Int'l Joint Research
• [Presentation] 市販医薬品の薬効成分の磁性化にむけて (2015)
  • Author(s): 梅村将就，勝亦真弓，小田香代子,佐藤格, 大竹誠, 青山春樹, 江口晴樹, 石川義弘.
  • Organizer: 遺伝子・デリバリー研究会 第15回 シンポジウム
  • Place of Presentation: 京都薬科大学 (京都府京都市）
  • Year and Date: 2015-05-01
• [Presentation] 市販医薬品の薬効成分の磁性化にむけて (2015)
  • Author(s): 梅村将就，勝亦真弓，小田香代子,佐藤格, 大竹誠, 青山春樹, 江口晴樹, 石川義弘.
  • Organizer: 遺伝子・デリバリー研究会 第15回 シンポジウム
  • Place of Presentation: 京都薬科大学(京都府京都市)
  • Year and Date: 2015-05-01
  • Invited
• [Presentation] Magnetized paclitaxel derivative for novel triple negative breast cancer therapy (2015)
  • Author(s): Ayako Makino, Masanari Umemura, Itaru Sato, Mayumi Katsumata, Akane Nagasako, Kayoko Oda, Makoto Ohtake, Haruki Aoyama, Haruki Eguchi, Yoshihiro Ishikawa
  • Organizer: 第88回日本薬理学会年次会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] A novel paclitaxel with intrinsic magnetism (2014)
  • Author(s): Ayako Makino, Masanari Umemura, Itaru Sato, Kayoko Oda, Makoto Otake, Akane Nagasako, Haruki Eguchi, Yoshihiro Ishikawa
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] A novel treatment for triple-negative breast cancer using intrinsic magnetized paclitaxel. (2014)
  • Author(s): Masanari Umemura, Ayako Makino, Itaru Sato, Xianfeng Feng, Maki Iwai, Kayoko Ito, Akiyoshi Miyajima, Makoto Otake, Akane Nagasako, Kosuke Matsuo, Haruki Eguchi, and Yoshihiro Ishikawa.
  • Organizer: The 105 American Association for Cancer Research Annual meeting
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2014-04-07 – 2014-04-11
• [Remarks] 横浜市立大学 循環制御医学 ホームページ
  • URL: http://www-user.yokohama-cu.ac.jp/~seiri1/gyouseki.html