| Project/Area Number |
26870493
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TSUCHIDA SHINJI 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10719834)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞間結合装置 / ギャップ結合 / コネキシン / 関節リウマチ / 滑膜炎 / connexin 43 |
|---|
| Outline of Final Research Achievements |
The expression of connexin 43 (Cx43) in synovial tissue from eight patients with RA , five patients with osteoarthritis, and one normal female subject was analyzed by quantitative reverse transcriptase polymerase chain reaction and immunohistochemistry of tissue sections. This study shows that Cx43 is expressed in RA synovial tissue and that its expression is induced by stimulation with TNF-a. The expression of the pro-inflammatory cytokines was inhibited by transfection of siCx43. Cx43 may be a novel marker of inflammation in RA synovial tissue.
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