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Identification of transmission pathway of pathological alpha-synuclein in non-transgenic mouse.

Research Project

Project/Area Number 26870494
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Nerve anatomy/Neuropathology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Taguchi Katsutoshi  京都府立医科大学, 医学(系)研究科(研究院), 助教 (60462701)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsalpha-Synuclein / Parkinson's disease / expression / inhibitory neuron / excitatory neuron / Synapse / Inhibitory neuron / Basal ganglia circuit
Outline of Final Research Achievements

alpha-Synuclein (aSyn), the major component of Lewy bodies, is normally expressed in presynapses and is involved in synaptic function. Accumulated evidence suggests that abundant intracellular expression of aSyn is one of the risk factors for pathological aggregation. Here we investigated the precise expression profile in the adult mouse brain with special reference to vulnerable regions along the progression of idiopathic Parkinson’s disease (PD). Our results show that aSyn was highly expressed in the neuronal cell bodies of some early PD-affected brain regions. Synaptic expression of aSyn was mostly accompanied by expression of excitatory presynaptic marker. In contrast, expression of aSyn in the inhibitory synapses was different among brain regions. These results suggest that some neurons in early PD-affected human brain regions express high levels of perikaryal aSyn, as happens in the mouse brain. Additionally, synaptic profiles expressing aSyn are different in various regions.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014 Other

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results) Remarks (2 results)

  • [Journal Article] Brain region-dependent differential expression of alpha-synuclein.2016

    • Author(s)
      Taguchi K, Watanabe Y, Tsujimura A, Tanaka M.
    • Journal Title

      J Comp Neurol.

      Volume: 524 Issue: 6 Pages: 1236-58

    • DOI

      10.1002/cne.23901

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] パーキンソン病関連分子α-シヌクレインを高発現する嗅球傍糸球体細胞の解析2016

    • Author(s)
      田口勝敏、渡邊義久、辻村敦、田中雅樹
    • Organizer
      第121回日本解剖学会総会全国学術集会
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] パーキンソン病関連分子α-Synuclein が示す多様な脳内発現プロファイルについて2015

    • Author(s)
      田口勝敏、渡邊義久、辻村敦、田中雅樹
    • Organizer
      第91回日本解剖学会学術集会・近畿支部会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Differential expression of alpha-synuclein with a cell-type dependent manner in vivo2015

    • Author(s)
      田口勝敏、渡邊義久、辻村敦、田中雅樹
    • Organizer
      第120回 日本解剖学会総会全国学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Differential expression of alpha-synuclein in vitro and in vivo2014

    • Author(s)
      田口勝敏、渡邊義久、辻村敦、田中雅樹
    • Organizer
      北米神経科学会 2014
    • Place of Presentation
      米国 ワシントンDC
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] レヴィ小体主要構成分子 alpha-Synuclein の脳内発現解析2014

    • Author(s)
      田口勝敏、渡邊義久、辻村敦、田中雅樹
    • Organizer
      第87回 日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Remarks] 京都府立医科大学 脳・血管系老化研究センター 基礎老化学

    • URL

      http://www.f.kpu-m.ac.jp/k/cellbio/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 京都府立医科大学 基礎老化学教室ホームページ

    • URL

      http://www.f.kpu-m.ac.jp/k/cellbio/

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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