Amyloid and tau imaging in the diagnosis of myopathy

• Project/Area Number: 26870497
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science; Neurology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: NOTO YUICHI 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50637270)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 封入体筋炎 / 多発性筋炎 / 皮膚筋炎 / PET / アミロイド / タウ

Outline of Final Research Achievements

To elucidate the utility of amyloid and tau imaging in the diagnosis of inclusion body myositis (IBM), whole muscle 11C-PIB- and 18F-FDDNP-positron emission tomogram (PET) scan was performed in 9 patients with IBM and 4 patients with inflammatory myopathy. In the 18F-FDDNP PET scan, there was no differences in the standardized uptake values (SUV) (which express local radioactivity concentration) between IBM and inflammatory myopathy groups. Regarding 11C-PIB-PET scan, averaged SUV measured from limb and trunk muscles was significantly higher in IBM patients than in inflammatory patients. Amyloid muscle imaging may be useful in differentiating IBM from inflammatory myopathy.