Bioavailability and bioactivity of dietary polyphenols.
| Project/Area Number |
26870506
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
Eating habits
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| Research Institution | University of Hyogo |
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Principal Investigator |
Ishisaka Akari 兵庫県立大学, 環境人間学部, 助教 (30724463)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | ポリフェノール / フラボノイド / ケルセチン / 脱抱合 / 炎症 / グルクロニダーゼ / スルファターゼ / モノクローナル抗体 |
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| Outline of Final Research Achievements |
Quercetin is the major polyphenol included in various fruits and vegetables. To understand the localization and target sites of quercetin underlying the bioactivity in vivo, we planned to develop monoclonal antibodies directed to quercetin aglycone and its degradation product. However, the developed antibodies scarcely recognized the haptens. These results suggested that the antibodies were difficult to available for immunochemical studies. On the other hands, we investigated the deconjugation mechanism of quercetin metabolites in healthy/inflammation animal models. This study suggested that the deconjugation of quercetin metabolites at sites of inflammation was contributed to the anti-inflammatory activity in vivo.
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Report
(4 results)
Research Products
(4 results)
