| Project/Area Number |
26870542
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
Embryonic/Neonatal medicine
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 未熟児医学 / 小児呼吸器学 / 高濃度酸素 / 新生児慢性肺疾患 / 性差 / 新生児 / 長期予後 / 気管支肺異形成 / 動物モデル / 呼吸機能 / 遺伝子発現解析 |
|---|
| Outline of Final Research Achievements |
Premature infants are often exposed to hyperoxia, which may lead to the development of chronic lung disease (CLD). Sex-specific differences exist in the development and severity of CLD. The aim of this study is to examine the sex-related long-term effects of neonatal hyperoxia on the lungs of adult mice. Newborn mice were exposed to 95% oxygen for 96 hours and were allowed to recover in room air to adulthood. Sex-related differences in pulmonary function, airway hyper-responsiveness, and lung structure in adult mice were assessed. Respiratory resistance was increased and sensitivity to methacholine was decreased in male adult mice following exposure to neonatal hyperoxia, whereas delayed alveolarization was observed in female adult mice following exposure to neonatal hyperoxia. The findings of the present study demonstrate that neonatal hyperoxia differentially affects pulmonary outcome in female and male adult mice.
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