| Project/Area Number |
26870543
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 再生医学 / 運動器 / 骨 / 骨格筋 / 間葉系幹細胞 / 転写共役因子 / 再生医療 |
|---|
| Outline of Final Research Achievements |
Groucho/TLE family members are transcriptional co-factors in metazoans that play critical roles during development and cell fate determination. We recently reported that TLE3, one of the Groucho/TLE family members, regulates the balance between osteoblast and adipocyte formation from mesenchymal stem cells (Kokabu S et al., 2013).
Here, we reported that canonical Wnt signaling increases the expression levels of TLE3 while TLE3 suppresses canonical Wnt signaling in bone marrow mesenchymal stem cells (Kokabu S et al., 2014). We also suggested the possibility that TLE expresses by satellite cells, skeletal muscle stem cells, and interacts with the bHLH domain of MyoD and interferes with the formation of a complex between MyoD and E-protein, which consequently results in repression of MyoD transcriptional activity and myogenesis.
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