The molecular basis of novel bone regeneration methods by regulating TLE3
| Project/Area Number |
26870543
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional basic dentistry
Surgical dentistry
|
|---|
| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 再生医学 / 運動器 / 骨 / 骨格筋 / 間葉系幹細胞 / 転写共役因子 / 再生医療 |
|---|
| Outline of Final Research Achievements |
Groucho/TLE family members are transcriptional co-factors in metazoans that play critical roles during development and cell fate determination. We recently reported that TLE3, one of the Groucho/TLE family members, regulates the balance between osteoblast and adipocyte formation from mesenchymal stem cells (Kokabu S et al., 2013).
Here, we reported that canonical Wnt signaling increases the expression levels of TLE3 while TLE3 suppresses canonical Wnt signaling in bone marrow mesenchymal stem cells (Kokabu S et al., 2014). We also suggested the possibility that TLE expresses by satellite cells, skeletal muscle stem cells, and interacts with the bHLH domain of MyoD and interferes with the formation of a complex between MyoD and E-protein, which consequently results in repression of MyoD transcriptional activity and myogenesis.
|
Report
(3 results)
Research Products
(24 results)
-
-
-
-
-
-
[Journal Article] Donepezil prevents RANK-induced boneloss via inhibitionofosteoclast differentiation by downregulating acetylcholinesterase.2015
Author(s)
Sato T, Enoki Y, Sakamoto Y, Yokota K, Okubo M, Matsumoto M, Hayashi N, Usui M, Kokabu S, Mimura T, Nakazato T, Araki N, Fukuda T, Okazaki Y, Suda T, Takeda S, Yoda T.
-
Journal Title
Heliyon
Volume: 1
Issue: 1
Pages: 1-20
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
[Journal Article] Post-tooth-extraction hemorrhage, thigh hematoma, and anemia in a patient receiving warfarin therapy.2015
Author(s)
Imai K, Kokabu S, Yamaguchi T, Fukushima Y, Nojima J, Sakata Y, Sato T, Sakaguchi H, Maruki T, Yoda T
-
Journal Title
Hosp Dent (Tokyo)
Volume: 2
Pages: 1-6
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
