Effects of glycine-Inhibition of sleep related bruxism and improvement of sleep
| Project/Area Number |
26870547
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Prosthodontics/ Dental materials science and
Surgical dentistry
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
Hino Shunsuke 埼玉医科大学, 医学部, 助教 (50614062)
|
|---|
| Research Collaborator |
ADACHI Kazunori 明海大学, 歯学部, 准教授 (20349963)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Keywords | 口腔外科学 / ブラキシズム / グリシン / 歯学 / 生理学 / 三叉神経 |
|---|
| Outline of Final Research Achievements |
The excitability of the jaw-opening reflex (JOR) is depressed during quiet sleep (QS). Because the systemic administration of glycine reduces sleep latency and the incidence of micro-arousals and increases JOR excitability during QS in rats, it has been hypothesized that the glycine receptor system in the trigeminal motor nucleus plays a role in the maintenance of sleep quality. In the present study, we investigated the effects of the microinjection of glycine or vehicle (isotonic saline) on JOR excitability and sleep quality in rats.
Compared with saline, each dose of glycine significantly reduced the JOR threshold during QS. Sleep latency and the incidence of micro-arousals were reduced, but not significantly, by 0.4 M glycine microinjection compared with saline. These findings suggest that the glycinergic system in the AD region of the trigeminal motor nucleus may be involved in the maintenance of sleep quality without affecting brain EEG excitability.
|
Report
(4 results)
Research Products
(8 results)
