Prevention of hepatic fat accumulation by habitual exercise and dietary restriction: Examination of a novel mechanism via adipose tissue

• Project/Area Number: 26870553
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits; Applied health science
• Research Institution: Wayo Women's University
• Principal Investigator: Kurosaka Yuka 和洋女子大学, 生活科学系, 助手 (30633002)
• Research Collaborator: MINATO Kumiko ; SHIROYA Yoko ; YAMAUCHI Hideki
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脂肪肝 / 肥満 / 運動習慣 / 食事制限 / 脂肪細胞サイズ / 運動 / 脂肪細胞 / 生活習慣 / 食餌制限

Outline of Final Research Achievements

In this study, we focused on adipocyte size and function to elucidate a novel means of preventing fatty liver development by habitual exercise and dietary restriction.
Fatty liver development was suppressed by a combination of habitual exercise and dietary restriction, but not by dietary restriction alone. Differences in adipocyte size and function were detected following combination of habitual exercise and dietary restriction versus dietary restriction alone. Weight management strategies that depend solely on dietary restriction may disrupt communication pathways related to fat metabolism between adipose tissue and the liver, thereby promoting the development of a fatty liver. By incorporating exercise, it is possible that this disruption can be avoided, and fatty liver development may be prevented.

Research Products

• [Journal Article] Protective effects of dietary restriction and physical exercise on intrahepatic fat accumulation (2018)
  • Author(s): Yuka Kurosaka, Hideki Yamauchi, Shigeru Takemori, Kumiko Minato
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 7 Issue: 1 Pages: 9-14
  • DOI: 10.7600/jpfsm.7.9
  • NAID: 130006315877
  • ISSN: 2186-8123, 2186-8131
  • Peer Reviewed / Open Access
• [Journal Article] Effects of habitual exercise and dietary restriction on intrahepatic and periepididymal fat accumulation in Zucker fatty rats. (2015)
  • Author(s): Kurosaka Y, Shiroya Y, Yamauchi H, Kaneko T, Okubo Y, Shibuya K, Minato K.
  • Journal Title: BMC Research Notes Volume: 8 Issue: 1 Pages: 121-121
  • DOI: 10.1186/s13104-015-1063-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Differential effects of diet restriction and exercise on lipolysis capacity in white adipose tissue (2015)
  • Author(s): Kurosaka, Y., Yamauchi, H., Shiroya, Y., Minato, K.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2015-05-14 – 2015-05-18
• [Presentation] Differential effects of diet restriction and exercise on lipolysis capacity in white adipose tissue (2015)
  • Author(s): Kurosaka, Y., Yamauchi, H., Shiroya, Y., Minato, K.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Pacifico Yokohama (Japan)
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] 運動・食餌制限による肝脂肪蓄積改善効果と脂肪組織との関連 (2014)
  • Author(s): 黒坂裕香，山内秀樹，代谷陽子，金子健彦，北村裕美，難波秀行，湊久美子．
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎大学文教キャンパス（長崎県）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] Effects of habitual exercise and diet restriction on the expression of hepatic carnitine palmitoyl-coa transferase-1 in zucker fatty rats (2014)
  • Author(s): Kurosaka, Y., Kitamura, H., Yamauchi, H., Shiroya, Y., Nanba, H., Minato, K.
  • Organizer: 19th Annual Congress of the European College of Sport Science
  • Place of Presentation: Amsterdam RAI Convention Centre (Amsterdam)
  • Year and Date: 2014-07-02 – 2014-07-05