| Project/Area Number |
26870556
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
Eating habits
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| Research Institution | Seitoku University |
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Principal Investigator |
Fukatsu Akiko 聖徳大学, 人間栄養学部, 講師 (10709778)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 低炭水化物食 / 食事脂肪 / 食後高血糖 / インスリン抵抗性 / 糖質代謝 / 脂質代謝 / アディポサイトカイン / 体組成 / 脂質 / 耐糖能 / コレステロール / 中性脂肪 / 体脂肪 / アディポネクチン / 炭水化物 / 糖尿病 / 食事療法 / 血糖管理 / 遵守度 / セカンドミール効果 |
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| Outline of Final Research Achievements |
We examined the effect of a low-carbohydrate, high-fat diet (LCHF diet; 30% carbohydrates, 45% fat) on the postprandial glucose response in healthy subjects. Although the LCHF diet improved postprandial glucose tolerance, in the second-meal analysis, increased the glucose response and the concentration for serum non-esterified fatty acids (NEFAs) and insulin. We concluded that LCHF meals induced insulin resistance at the second meal with increased NEFAs.
Subsequently, we evaluated the effect of a 7-day moderately low-carbohydrate diet (MLC diet; 40% carbohydrates, 35% fat) on glucose and lipid metabolism. The MLC diet decreased serum triglyceride and adiponectin levels and did not alter serum low-density lipoprotein cholesterol.
We concluded that we should plan low-carbohydrate diets considering the effects of fat on glucose and lipid metabolism. These findings need to be confirmed in longer-term studies that also include subjects with diabetes.
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