| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
In this study, the associations between gene polymorphisms and rates of Helicobacter pylori (H. pylori) eradication response in patients with H.pylori-associated immune thrombocytopenia (ITP) were evaluated. Patients with ITP who were carriers of the FcγRIIB 232T or TGF-β -509T polymorphisms had significantly higher rates of H. pylori eradication responses than non-carriers. The frequency of the circulating anti-glycoprotein IIb/IIIa antibody-producing cells was significantly higher in patients with ITP that carried the FcγRIIB 232T allele than in those with the non-T allele. In addition, patients with ITP that carried the TGF-β -509T allele tended to have lower TGF-β levels. These findings suggest that FcγRIIB 232I/T and TGF-β -509C/T gene polymorphisms contribute to the susceptibility of H.pylori-associated ITP by controlling the autoimmune responses.
|
